Results 211 to 220 of about 1,163,135 (344)

Graphtyper enables population-scale genotyping using pangenome graphs

Nature Genetics, 2017
H. Eggertsson, Hákon Jónsson, Snaedis Kristmundsdottir, Eirikur Hjartarson, Birte Kehr, G. Másson, Florian Zink, K. E. Hjorleifsson, Á. Jónasdóttir, Adalbjorg Jonasdottir, I. Jónsdóttir, D. Gudbjartsson, P. Melsted, K. Stefánsson, B. Halldórsson   +14 more
semanticscholar   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

Protocol for high-quality RNA sequencing, cell surface protein analysis, and genotyping in single cells using TARGET-seq. [PDF]

STAR Protoc
Jakobsen NA, Turkalj S, Vyas P.
europepmc   +1 more source

Photoperiod, Temperature and Genotype Interactions Affecting Time of Flowering in Beans, Phaseolus vulgaris L.1 [PDF]

, 1969
D. S. Padda, H. M. Munger
openalex   +1 more source

MTCH2 Deficiency Promotes E2F4/TFRC‐Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

Advanced Science, EarlyView.
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing, Jiangbo Chen, Hao Hao, Xiaowen Qiao, Xinying Yang, Kai Weng, Jie Chen, Lin Song, Tianqi Liu, Yifan Hou, Tongkun Song, Yumeng Ran, Bo Chen, Hong Yang, Wei Zhao, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su   +18 more
wiley   +1 more source

Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs. [PDF]

Proc Natl Acad Sci U S A
Bizzotto S, Talukdar M, Stronge EA, Ramirez RB, Yang Y, Huang AY, Hu Q, Hou Y, Hylton NK, Finander B, Tillett A, Zhou Z, Chhouk BH, D'Gama AM, Yang E, Green TE, Reutens DC, Mullen SA, Scheffer IE, Hildebrand MS, Buono RJ, Blümcke I, Poduri AH, Khoshkhoo S, Walsh CA.   +24 more
europepmc   +1 more source

The relationship between number, position in the fruit and genotype of tomato seeds.

, 1968
N. Kedar, K. Verkerk
openalex   +2 more sources

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

Assessing the sequencing success and analytical specificity of a targeted amplicon deep sequencing workflow for genotyping the foodborne parasite <i>Cyclospora</i>. [PDF]

J Clin Microbiol
Peterson AC, Jacobson D, Richins T, Barratt J, Qvarnstrom Y.   +4 more
europepmc   +1 more source

Environmental and genotype-environmental components of variability V. Segregating Generations [PDF]

, 1969
L Bucio Alanis, Jean M Perkins, J L Jinks   +2 more
openalex   +1 more source