Results 221 to 230 of about 1,163,135 (344)

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Development of a cost-effective high-throughput mid-density 5K genotyping assay for germplasm characterization and breeding in groundnut. [PDF]

Plant Genome
Pandey MK, Sharma V, Khan AW, Joshi P, Gangurde SS, Bajaj P, Janila P, Chitikineni A, Bhat R, Motagi BN, Sangh C, Radhakrishnan T, Bera SK, Gorjanc G, Gujjula KR, Hall N, Carrasco CD, Arjun K, Chandram S, Varshney RK.   +19 more
europepmc   +1 more source

Environmental stress, heterozygote advantage and genotype-environment interaction in Arabidopsis [PDF]

, 1968
D. G. Pederson
openalex   +1 more source

Noninvasive Detection of Response and Resistance in EGFR-Mutant Lung Cancer Using Quantitative Next-Generation Genotyping of Cell-Free Plasma DNA

Clinical Cancer Research, 2014
G. Oxnard, C. Paweletz, Y. Kuang, Stacy L. Mach, Allison O'Connell, M. Messineo, J. Luke, M. Butaney, P. Kirschmeier, D. Jackman, P. Jänne   +10 more
semanticscholar   +1 more source

ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7

Advanced Science, EarlyView.
Histone lysine crotonylation (Kcr) is a highly conserved posttranslational modification implicated with crucial biological processes. This study reveals that ACSS2‐mediated H4K12cr upregulated CLDN7 transcription to strengthen intestinal epithelial barrier.
Ming Yuan, Shaopeng Chen, Zhensen Lin, Runfeng Yu, Kang Chao, Shubiao Ye, Qing Li, Haoxian Ke, Chi Zhang, Junfeng Huang, Guanzhan Liang, Tuo Hu, Xiang Gao, Ping Lan, Xianrui Wu   +14 more
wiley   +1 more source

Establishing Best Practices for Clinical GWAS: Tackling Imputation and Data Quality Challenges. [PDF]

Int J Mol Sci
Casaburi G, McCullough R, D'Argenio V.
europepmc   +1 more source

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Nature Genetics, 2013
K. Michailidou, P. Hall, A. González-Neira, M. Ghoussaini, J. Dennis, R. Milne, M. Schmidt, J. Chang-Claude, S. Bojesen, M. Bolla, Qin Wang, E. Dicks, Andrew Lee, C. Turnbull, N. Rahman, O. Fletcher, J. Peto, L. Gibson, I. dos Santos Silva, H. Nevanlinna, T. Muranen, K. Aittomäki, C. Blomqvist, K. Czene, A. Irwanto, Jianjun Liu, Q. Waisfisz, H. Meijers-Heijboer, M. Adank, R. B. van der Luijt, R. Hein, N. Dahmen, L. Beckman, A. Meindl, R. Schmutzler, B. Müller-Myhsok, P. Lichtner, J. Hopper, M. Southey, E. Makalic, D. Schmidt, A. Uitterlinden, A. Hofman, D. J. Hunter, S. Chanock, Daniel Vincent, F. Bacot, D. Tessier, S. Canisius, L. Wessels, C. Haiman, M. Shah, R. Luben, Judith E. Brown, C. Luccarini, N. Schoof, K. Humphreys, Jingmei Li, B. Nordestgaard, S. F. Nielsen, H. Flyger, F. Couch, Xianshu Wang, C. Vachon, Kristen Stevens, D. Lambrechts, M. Moisse, R. Paridaens, M. Christiaens, A. Rudolph, S. Nickels, D. Flesch-Janys, N. Johnson, Z. Aitken, Kirsimari Aaltonen, T. Heikkinen, A. Broeks, Laura van't Veer, C. E. van der Schoot, P. Guénel, Thérèse Truong, P. Laurent-Puig, F. Menegaux, F. Marmé, A. Schneeweiss, C. Sohn, B. Burwinkel, M. P. Zamora, J. I. Peŕez, G. Pita, M. Alonso, A. Cox, I. Brock, S. Cross, M. Reed, E. Sawyer, I. Tomlinson, M. Kerin, N. Miller, B. Henderson, F. Schumacher, L. Le Marchand, I. Andrulis, J. Knight, G. Glendon, A. Mulligan, A. Lindblom, S. Margolin, M. Hooning, A. Hollestelle, A. V. D. van den Ouweland, A. Jager, Q. Bui, J. Stone, G. Dite, C. Apicella, H. Tsimiklis, G. Giles, G. Severi, L. Baglietto, P. Fasching, L. Haeberle, A. Ekici, M. Beckmann, H. Brenner, Heiko Müller, V. Arndt, C. Stegmaier, A. Swerdlow, A. Ashworth, N. Orr, Michael P. Jones, J. Figueroa, J. Lissowska, L. Brinton, M. Goldberg, F. Labrèche, M. Dumont, R. Winqvist, K. Pylkäs, A. Jukkola-Vuorinen, Mervi Grip, H. Brauch, U. Hamann, T. Brüning, P. Radice, P. Peterlongo, S. Manoukian, B. Bonanni, P. Devilee, R. Tollenaar, C. Seynaeve, C. V. van Asperen, A. Jakubowska, J. Lubiński, Katarzyna Jaworska, K. Durda, A. Mannermaa, V. Kataja, V. Kosma, Jaana M. Hartikainen, N. Bogdanova, N. Antonenkova, T. Dörk, V. Kristensen, H. Anton-Culver, S. Slager, A. Toland, Stephen Edge, F. Fostira, D. Kang, K. Yoo, D. Noh, K. Matsuo, Hidemi Ito, H. Iwata, Aiko Sueta, A. Wu, C. Tseng, D. J. Van Den Berg, D. Stram, X. Shu, W. Lu, Yu-Tang Gao, H. Cai, S. Teo, C. Yip, S. Phuah, Belinda K. Cornes, M. Hartman, H. Miao, W. Lim, J. Sng, K. Muir, A. Lophatananon, S. Stewart-Brown, Pornthep Siriwanarangsan, Chen-Yang Shen, Chia-Ni Hsiung, Pei‐Ei Wu, S. Ding, S. Sangrajrang, V. Gaborieau, P. Brennan, J. Mckay, W. Blot, L. Signorello, Q. Cai, W. Zheng, Sandra L. Deming-Halverson, M. Shrubsole, J. Long, J. Simard, M. García-Closas, Paul D. P. Pharoah, G. Chenevix-Trench, A. Dunning, J. Benítez, D. Easton   +218 more
semanticscholar   +1 more source

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source

Modelling the cost-effectiveness of cervical cancer screening with HPV self-sampling and molecular triage for women aged 60-69 years. [PDF]

Discov Oncol
Fridljung J, Bergengren L, Ryen L, Lillsunde Larsson G.   +3 more
europepmc   +1 more source

CRITICAL RELATIONSHIPS BETWEEN CONSTITUENTS OF THE ANTIGEN-ADJUVANT EMULSION AFFECTING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN A COMPLETELY SUSCEPTIBLE MOUSE GENOTYPE [PDF]

, 1962
Johanna M. Lee, Howard A. Schneider
openalex   +1 more source