Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang+6 more
wiley +1 more source
Leveraging transcriptome-wide association studies identifies the relationship between upper respiratory flora and cell type-specific gene expression in severe respiratory disease. [PDF]
Xu L+7 more
europepmc +1 more source
Japanese encephalitis virus (JEV) employs a cap‐independent (CI) translation strategy to evade host translational shutoff. During the shut‐off of host cellular canonical translation, DEAD‐box protein 3 (DDX3) bind to JEV UTRs to establish a closed‐loop architecture, and its interaction with poly(A)‐binding protein 1 (PABP1) to form DDX3/PABP1/eIF4G ...
Chenxi Li+13 more
wiley +1 more source
Ascomycota: Diversity, Taxonomy and Phylogeny, 2nd Edition: Editorial. [PDF]
Dissanayake AJ, Liu JK.
europepmc +1 more source
Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang+13 more
wiley +1 more source
Phylogenomic studies and molecular markers clarifying the evolutionary relationships and classification of <i>Pseudalkalibacillus</i> species: proposal for the family <i>Guptibacillaceae</i> fam. nov. harbouring the genera <i>Guptibacillus</i> gen. nov. and <i>Exobacillus</i> gen. nov. [PDF]
Bello S, Rudra B, Schellhorn HE.
europepmc +1 more source
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma+9 more
wiley +1 more source
<i>Gracilimonas qinghaiensis</i> sp. nov., a halophilic bacterium from a high-altitude saline lake exhibiting diverse metabolic potential and ecological adaptation. [PDF]
Wang H+8 more
europepmc +1 more source