Results 71 to 80 of about 25,740 (248)

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Effects of Heavy Metal Contamination Caused by Residual Leachate on Forest Soil in Babol Anjilsi Region, Iran

تحقيقات جغرافيايی, 2020
Aims & Backgrounds: The heavy metals are a part of the minor elemental elements in the nature. Forest soils directly and indirectly affect public health through the production of nutritional factors on plants and animals in the ecosystem.
Mohammad Rahmani, Tahereh Azari, Sareh Mollaaghajanzadeh   +2 more
doaj  

Assessment of Heavy Metal Contamination in Soils of Gashaka Local Government Area, Nigeria Using Geo-Accumulation Index

Journal of Geography, Environment and Earth Science International
Anthropogenic activities such as mining, improper waste disposal, and agricultural practices have contributed significantly to heavy metal contamination in soils, posing substantial ecological and public health risks. This study assessed the levels of heavy metal contamination in soils across four locations: Lambangudu, Maijankasa, Gidan Kara Bodel ...
D.G., Musa, L.D., David, Y.M., Ahmed, E., Allahnanan, M.M., Joshua, A., Hauwa   +5 more
openaire   +2 more sources

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Geo-accumulation Index of Heavy Metals in River Ogu Water Sediment in Onne Area, Southern Nigeria

Abstract This study examined the accumulation of contaminants in Ogu River sediments, primarily caused by illegal bunkering activities occurring along the watercourses and riverbanks. Additionally, the operations of local refinery operators and other significant chemical and petrochemical industries in the area significantly contribute to the ...
Omoko, Ejiro Newton, Adikwu, Stephen Onum, Ocheli, Azuka, Amiewalam, Florence Odega, Oyem, Michael Ndubueze, Nmorsi, Dumbiri Dandy, Nimnu, Joy Rosemary   +6 more
openaire   +2 more sources

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Evaluation of Potential Toxic Elements in Soils from Three Urban Areas Surrounding a Steel Industrial Zone

Toxics
The urban zone around the city of Volos, a Greek city with a historically industrialized profile, faces threats arising from Potential Toxic Element (PTE) contamination. The scope of this study is to determine the contamination levels of 10 PTEs in three
Georgios Charvalas, Aikaterini Molla, Alexios Lolas, Elpiniki Skoufogianni, Savvas Papadopoulos, Evaggelia Chatzikirou, Christina Emmanouil, Olga Christopoulou   +7 more
doaj   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Geo-accumulation Index, Enrichment Factor and Quantification of Contamination of Heavy Metals in Soil Receiving Cassava Mill Effluents in A Rural Community in the Niger Delta Region of Nigeria

Molecular Soil Biology, 2017
This study investigated enrichment factor, geo-accumulation index and quantification of contamination of heavy metals in cassava mill effluents contaminated soil by smallholder cassava processors in a rural community in the Niger Delta region of Nigeria. Data used for the environmental risk assessment is from secondary sources.
Sylvester Chibueze Izah, Sunday Etim Bassey, Elijah Ige Ohimain   +2 more
openaire   +1 more source