Results 321 to 330 of about 1,882,464 (376)

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Regulatory role of phosphatidylcholine metabolic reprogramming in colorectal cancer progression and neutrophil interactions. [PDF]

iScience
Cheng F, Huang L, Peng Y, Luo L, Zhong L, Ju Y, Lu Y, Ouyang M.   +7 more
europepmc   +1 more source

A Conjugation Delivery System of Macrophages and Platelet Pharmacytes Promotes Regeneration After Spinal Cord Injury

Advanced Science, EarlyView.
A macrophage–platelet conjugation system (M‐P‐NPs@PPARγ) targets injure tissue to co‐deliver platelet mitochondria and PPARγ‐encoding NPs. This strategy boosts the macrophage energy supply and restores lipid homeostasis, leading to synergistically enhanced efferocytosis and tissue repair Abstract Mitochondrial dysfunction occurs in macrophages with ...
Haoli Wang, Hao Hu, Yijun Li, Lintao Hu, Chenhui Gu, Yiwei Zhu, Jing Huang, Na Li, Shuqi Jiang, Shouyan Zu, Jiachen Xu, Yining Wang, Ke Yang, Pengfei Chen, Liqing Shangguan, Yongcheng Wang, Shunwu Fan, Xianfeng Lin, Qingqing Wang   +18 more
wiley   +1 more source

Ubiquitin D Correlates with Disease Severity and T Cell Infiltration in Cholestasis: Evidence from Integrated Bioinformatics and Experimental Analyses. [PDF]

Int J Med Sci
Wang H, Zhang J, Huang X, Peng S.
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

An integrated machine learning framework for developing a transcriptomic analysis and machine learning-based diagnostic model of gout based on sleep disorder-related genes. [PDF]

Medicine (Baltimore)
Lu F, Yang F, Yang W.
europepmc   +1 more source

5G Non-Terrestrial Networks With OpenAirInterface: An Experimental Study Over GEO Satellites

Florian Völk, Thomas Schlichter, Sumit Kumar, Robert T. Schwarz, Andreas Knopp, Marwan Hammouda, Thomas Heyn, Jorge Querol, Symeon Chatzinotas, Adam Kapovits   +9 more
openalex   +1 more source

Machine learning identifies inflammation-related diagnostic biomarkers for primary myelofibrosis with clinical validation. [PDF]

Sci Rep
Li R, Han Q, Zeng T, Wen B, Zheng Z, Bao X, Huang J.   +6 more
europepmc   +1 more source

Early diagnostic biomarkers for acute myocardial infarction unveiled by metabolomics, Mendelian randomization, and machine learning. [PDF]

Mol Biomed
Fan H, Fu X, Guo Q, Jia F, Wei XY, Liu J, Zhang N, Zhu C, Shi J, Zhang L, Li JC.   +10 more
europepmc   +1 more source

Genes associated with epithelial mesenchymal transition (EMT) in cervical cancer progression. [PDF]

Discov Oncol
Kumari K, Gupta RK, Kumar S, Prasad SB.
europepmc   +1 more source