Results 71 to 80 of about 1,882,464 (376)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

The DIGMAP geo-temporal web gazetteer service [PDF]

open access: yes, 2009
This paper presents the DIGMAP geo-temporal Web gazetteer service, a system providing access to names of places, historical periods, and associated geo-temporal information.
Borbinha, José   +3 more
core   +1 more source

Thermal Geo-axions

open access: yes, 2009
We estimate the production rate of axion-type particles in the core of the Earth, at a temperature T~5000K. We constrain thermal geo-axion emission by demanding a core-cooling rate less than 100K/Gyr, as suggested by geophysics.
G. G. Raffelt   +2 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

PTPLAD2 and USP49 Involved in the Pathogenesis of Smoke-Induced COPD by Integrative Bioinformatics Analysis

open access: yesInternational Journal of COPD, 2020
Qiang Zhang,1 Wei Song,1 Nahemuguli Ayidaerhan,2 Zheng He3 1Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province 110042, People’s Republic of China; 2Department of Pulmonary
Zhang Q, Song W, Ayidaerhan N, He Z
doaj  

The role, opportunities and challenges of 3D and geo-ICT in archaeology [PDF]

open access: yes, 2014
Archaeology joins in the trend of three-dimensional (3D) data and geospatial information technology (geo-ICT). Currently, the spatial archaeological data acquired is 3D and mostly used to create realistic visualizations. Geographical information systems (
Bourgeois, Jean   +2 more
core  

Cross-View Image Matching for Geo-localization in Urban Environments

open access: yes, 2017
In this paper, we address the problem of cross-view image geo-localization. Specifically, we aim to estimate the GPS location of a query street view image by finding the matching images in a reference database of geo-tagged bird's eye view images, or ...
Chen, Chen, Shah, Mubarak, Tian, Yicong
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Contemporary trends in the development of public procurement law in South Africa

open access: yesRuch Prawniczy, Ekonomiczny i Socjologiczny, 2023
This paper explores emerging contemporary trends in the development of South Africa’s public procurement law. Using a doctrinal legal analysis, it identifies two main trends in such development post-democratization, one structural and one substantive ...
Geo Quinot
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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