Results 101 to 110 of about 21,775 (287)

Determinants of cone- and rod-function in geographic atrophy: AI-based structure-function correlation

, 2020
Purpose To investigate the association between retinal microstructure and cone- and rod-function in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) using artificial-intelligence-(AI) algorithms.
Fleckenstein, Monika, Lindner, Moritz, Moller, Philipp T., Schmid, Matthias, Pfau, Maximilian, Dysli, Chantal, von der Emde, Leon, Holz, Frank G., Rubin, Daniel L, Schmitz-Valckenberg, Steffen, Möller, Philipp T, Rubin, Daniel L., Holz, Frank G, Thiele, Sarah   +13 more
core   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Interactive segmentation for geographic atrophy in retinal fundus images

, 2008
Fundus auto-fluorescence (FAF) imaging is a non-invasive technique for in vivo ophthalmoscopic inspection of age-related macular degeneration (AMD), the most common cause of blindness in developed countries. Geographic atrophy (GA) is an advanced form of
Lee, Noah, R. Theodore Smith, Andrew F. Laine, Noah Lee, Laine, Andrew F., Smith, R. Theodore   +5 more
core   +1 more source

Barriers and Enablers for Effective Support Coordination in the National Disability Insurance Scheme

Australian Journal of Social Issues, EarlyView.
ABSTRACT Support coordinators act as intermediaries between the National Disability Insurance Scheme (NDIS) and participants, facilitating access to funded supports. To optimise outcomes, they must navigate NDIS complexities, identify services that meet individual needs and engage with diverse stakeholders.
Sharyn McDonald, Lee Cubis, Di Winkler, Jacinta Douglas   +3 more
wiley   +1 more source

Readiness of optometrists in the management of geographic atrophy: a survey of optometrists in Australia

CLINICAL RELEVANCE: Geographic atrophy is a leading cause of severe vision loss and is estimated to affect around 100,000 people in Australia alone. This survey is topical for clinical optometrists as the first treatment for geographic atrophy has just ...
Arnold, J, Abbott, CJ, Chen, FK, Guymer, RH, Hunyor, AP, Lim, LL   +5 more
core   +1 more source

Olfactory Bulb Volume Reflects Olfactory Dysfunction and Network Organization: Insights From the Population‐Based Rhineland Study

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory dysfunction is common in aging and an early symptom of neurodegenerative diseases, but how structural (olfactory bulb [OB] volume) and functional (olfactory network [OFN] functional connectivity [FC]) brain features interact to shape odor identification ability remains unclear.
Weiyi Zeng, Konstantinos Melas, Santiago Estrada, N. Ahmad Aziz, Monique M. B. Breteler   +4 more
wiley   +1 more source

Demographics and main clinical features of the study population affected with geographic atrophy.

, 2016
Demographics and main clinical features of the study population affected with geographic atrophy.
Eleonora Corbelli (3360860), Adriano Carnevali (3360857), Lea Querques (3360866), Francesco Bandello (750203), Giuseppe Querques (2267224), Luigi Antonio De Vitis (3360851), Riccardo Sacconi (3360863), Alessandro Rabiolo (3360854)   +7 more
core   +1 more source

Estimating Uncertainty of Geographic Atrophy Segmentations with Bayesian Deep Learning

Ophthalmology Science
Purpose: To apply methods for quantifying uncertainty of deep learning segmentation of geographic atrophy (GA). Design: Retrospective analysis of OCT images and model comparison.
Theodore Spaide, PhD, Anand E. Rajesh, MD, Nayoon Gim, Marian Blazes, MD, Cecilia S. Lee, MD, MS, Niranchana Macivannan, PhD, Gary Lee, PhD, MEng, Warren Lewis, MS, Ali Salehi, PhD, Luis de Sisternes, PhD, Gissel Herrera, MD, Mengxi Shen, MD, PhD, Giovanni Gregori, PhD, Philip J. Rosenfeld, MD, PhD, Varsha Pramil, MD, MS, Nadia Waheed, MD, MPH, Yue Wu, PhD, Qinqin Zhang, PhD, Aaron Y. Lee, MD, MSCI   +18 more
doaj   +1 more source

ApoE‐ and Cfh‐deficient mice exhibit structural and molecular features of human early–intermediate retinal degeneration

Animal Models and Experimental Medicine, EarlyView.
Age‐related macular degeneration (AMD) involves lipid dysregulation and complement overactivation. Here, we characterize a double‐knockout ApoE−/−/Cfh−/− mouse as a model of early–intermediate retinal degeneration. These mice exhibit retinal pigment epithelium thinning, Bruch's membrane thickening, lipid accumulation, enhanced C5b‐9 deposition ...
Sergio Recalde, Maite Moreno Orduña, Jaione Bezunartea, Idoia Belza, Ainara Chas, Laura Fernández‐Sánchez, Nicolás Cuenca Navarro, Alfredo García‐Layana, Patricia Fernández‐Robredo, María Hernández   +9 more
wiley   +1 more source

RPE and Choroid Translocation in Geographic Atrophy

A major goal in surgery of geographic atrophy is the atraumatic creation of a submacular space by subretinal injection of BSS. Often the retinal-RPE-Choroid-adhesion is to tight, that water is insufficient. Then a spatula manoevre is advised with the tip
eyeMoviePedia gGmbH, Kirchhof, Bernd
core   +1 more source