Results 31 to 40 of about 145,156 (217)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Geometric configurations of singularities for quadratic differential systems with total finite multiplicity $m_f=2$

Electronic Journal of Differential Equations, 2014
In this work we consider the problem of classifying all configurations of singularities, both finite and infinite of quadratic differential systems, with respect to the geometric equivalence relation defined in [3].
Joan C. Artes, Jaume Llibre, Dana Schlomiuk, Nicolae Vulpe   +3 more
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Deformation Quantization of Poisson Structures Associated to Lie Algebroids

Symmetry, Integrability and Geometry: Methods and Applications, 2009
In the present paper we explicitly construct deformation quantizations of certain Poisson structures on E*, where E → M is a Lie algebroid. Although the considered Poisson structures in general are far from being regular or even symplectic, our ...
Nikolai Neumaier, Stefan Waldmann
doaj   +1 more source

Thermodynamic properties of modified gravity theories

, 2016
We review thermodynamic properties of modified gravity theories such as $F(R)$ gravity and $f(T)$ gravity, where $R$ is the scalar curvature and $T$ is the torsion scalar in teleparallelism. In particular, we explore the equivalence between the equations
Bamba, Kazuharu
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Local moves on spatial graphs and finite type invariants [PDF]

, 2001
We define $A_k$-moves for embeddings of a finite graph into the 3-sphere for each natural number $k$. Let $A_k$-equivalence denote an equivalence relation generated by $A_k$-moves and ambient isotopy. $A_k$-equivalence implies $A_{k-1}$-equivalence. Let $
Taniyama, Kouki, Yasuhara, Akira
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Derivatives of Knots and Second-order Signatures

, 2010
We define a set of "second-order" L^(2)-signature invariants for any algebraically slice knot. These obstruct a knot's being a slice knot and generalize Casson-Gordon invariants, which we consider to be "first-order signatures".
Casson, Casson, Cheeger, Constance Leidy, Gilmer, Hillman, Lamm, Lück, Shelly Harvey, Strebel, Tim D Cochran   +10 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source