Results 41 to 50 of about 2,632,024 (290)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Geometric error detection of curve-face gear pairs

Advances in Mechanical Engineering, 2016
A new type of gear pair, the curve-face gear pair, composed of a curve-face gear and a non-circular gear with mutual engagement, was proposed to achieve variable ratio transmission of motion and power between the intersecting axes.
Chao Lin, Chao Huang, Xi-Jun Cao, Yu Fan
doaj   +1 more source

Selective polishing method to increase precision in large format lightweight machine tools working with petrous material

Revista Facultad de Ingeniería Universidad de Antioquia, 2019
In this article two complementary methods are developed. Firstly, a method to add precision in large machine tools with modular lightweight structures (APLM), which performs the compensation of geometrics and dynamics errors using embedded intelligence,
Orlando de Jesús Copete-Murillo, Iván Darío Arango-López   +1 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Rapid Measurement and Identification Method for the Geometric Errors of CNC Machine Tools

Applied Sciences, 2019
Error compensation technology offers a significant means for improving the geometric accuracy of CNC machine tools (MTs) as well as extending their service life. Measurement and identification are important prerequisites for error compensation.
Xinghua Li, Xiaohuan Yang, Lingyu Gao, Zhikun Su, Xuan Wei, Zekui Lv, Jiaqi Liang, Haopeng Li, Fengzhou Fang   +8 more
doaj   +1 more source

Modeling of CNC machine tools’ spatial geometric error based on two-dimensional angle error

SN Applied Sciences, 2022
A modeling method of CNC machine tools’ spatial geometric error is proposed based on two-dimensional angle error in this paper. Different from traditional modeling method, this method takes into account the effect of additional angle errors because the ...
Xiuqin Zhang, Guohua Chen, Lin Zhang, Yongwen Hu, Jie Mao, Zhiyang Zhang   +5 more
doaj   +1 more source

Nonasymptotic bounds on the mean square error for MCMC estimates via renewal techniques [PDF]

, 2011
The Nummellin’s split chain construction allows to decompose a Markov chain Monte Carlo (MCMC) trajectory into i.i.d. "excursions". Regenerative MCMC algorithms based on this technique use a random number of samples.
Miasojedow, Błażej, Łatuszyński, Krzysztof, Niemiro, Wojciech, Miasojedow, Blazej, Latuszynski, Krzysztof   +4 more
core  

The Effect of Distinct Geometric Semantic Crossover Operators in Regression Problems [PDF]

, 2015
This paper investigates the impact of geometric semantic crossover operators in a wide range of symbolic regression problems. First, it analyses the impact of using Manhattan and Euclidean distance geometric semantic crossovers in the learning process ...
Albinati, Julio, Otero, Fernando E.B., Julio Albinati, Luiz Otávio V. B. Oliveira, Gisele L. Pappa, Pappa, Gisele L., Oliveira, Luiz Otávio V.B., Fernando E. B. Otero   +7 more
core   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source