Results 71 to 80 of about 3,035,036 (296)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Comparative analysis of the results of determining the parameters of the stress-strain state of equal slope shell

Structural Mechanics of Engineering Constructions and Buildings, 2019
Relevance. Thin-walled structures of shells constitute a large class in architecture, in civil and industrial construction, mechanical engineering and instrument making, aircraft, rocket and shipbuilding, etc.
Vyacheslav N. Ivanov, Olga O. Alyoshina
doaj   +1 more source

Interval methods in geometric modeling

Proceedings Geometric Modeling and Processing 2000. Theory and Applications, 2000
This paper is about using interval computations in location, simplification, and root-finding for multivariate implicit functions that are used as shape primitives in a set-theoretic (that is, a CSG) geometric modeller. Three problems are discussed, and solutions to them presented: the location and simplification of the surfaces of semialgebraic sets ...
Bowyer, A, Berchtold, J, Eisenthal, D, Voiculescu, I, Wise, K   +4 more
openaire   +2 more sources

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

A Multi-Objective Approach for Optimizing Aisle Widths in Underground Parking

Infrastructures
This study presents a multi-objective optimization approach for determining optimal aisle widths in underground parking facilities, balancing vehicle maneuverability against parking capacity.
Igor Kabashkin, Alua Kulmurzina, Assel Zhandarbekova, Zura Sansyzbayeva, Timur Sultanov   +4 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Geometric Discretization of Lagrangian Mechanics and Field Theories [PDF]

, 2009
This thesis presents a unified framework for geometric discretization of highly oscillatory mechanics and classical field theories, based on Lagrangian variational principles and discrete differential forms. For highly oscillatory problems in mechanics,
Stern, Ari Joshua
core   +1 more source

Agustin de Betancourt’s Wind Machine for Draining Marshy Ground: Approach to Its Geometric Modeling with Autodesk Inventor Professional

Technologies, 2016
The present study shows the process followed in making the three-dimensional model and geometric documentation of a historical invention of the renowned Spanish engineer Agustin de Betancourt y Molina, which forms part of his rich legacy.
José Ignacio Rojas-Sola, Eduardo de la Morena-de la Fuente   +1 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source