Results 71 to 80 of about 173,618 (310)

Categorisation of designs according to preference values for shape rules

, 2008
Shape grammars have been used to explore design spaces through design generation according to sets of shape rules with a recursive process. Although design space exploration is a persistent issue in computational design research, there have been few ...
Chase, Scott, EPSRC (Funder), , AHRC (Funder), , EPSRC (Funder), Lim, Sungwoo, Garner, Steve, AHRC (Funder), Prats, Miquel   +7 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Data-Driven Research on the Matching Degree of Eyes, Eyebrows and Face Shapes

Frontiers in Psychology, 2019
There is a close relationship between the attractiveness of the face and the facial features. The shape of the facial features determines the level of attractiveness, in which the eyes and eyebrows are particularly vital.
Jian Zhao, Meng Zhang, Chen He, Kainan Zuo   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Mathematical expression method for geometric shape of toroidal propeller

Zhongguo Jianchuan Yanjiu
ObjectivesThe toroidal propeller can effectively reduce tip vortex leakage due to its unique shape, which is beneficial for reducing hydrodynamic noise and improving propulsion efficiency. However, its complex shape also makes it challenging to model its
Liyu YE, Chao WANG, Cong SUN, Chunyu GUO
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Rotationally invariant 3D shape contexts using asymmetry patterns [PDF]

, 2013
This paper presents an approach to resolve the azimuth ambiguity of 3D Shape Contexts (3DSC) based on asymmetry patterns. We show that it is possible to provide rotational invariance to 3DSC at the expense of a marginal increase in computational load ...
Sukno, Federico M., Waddington, John L., Whelan, Paul F.   +2 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Geometric shape parameterization of multidimensional finite non-regular point sets

Омский научный вестник
The paper is devoted to a formal approach to parameterization the geometric shape of spatial point irregular sets in multidimensional Euclidean space.
V. Yu. Yurkov, M. A. Chizhik
doaj   +1 more source