Results 71 to 80 of about 3,122,764 (234)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Automated detection, labelling and radiological grading of clinical spinal MRIs
Scientific ReportsSpinal magnetic resonance (MR) scans are a vital tool for diagnosing the cause of back pain for many diseases and conditions. However, interpreting clinically useful information from these scans can be challenging, time-consuming and hard to reproduce ...
Rhydian Windsor +3 more
doaj +1 more source
Retention time prediction for chromatographic enantioseparation by quantile geometry-enhanced graph neural network [PDF]
, 2023 Hao Xu +3 more
openalex +1 more source
Dagger geometry as Banach algebraic geometry
Journal of Number Theory, 2016 In this article, we apply the approach of relative algebraic geometry towards analytic geometry to the category of bornological and Ind-Banach spaces (non-Archimedean or not). We are able to recast the theory of Grosse-Klönne dagger affinoid domains with their weak G-topology in this new language.
Bambozzi F., Ben-Bassat O.
openaire +3 more sources
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
On Bloch’s map for torsion cycles over non-closed fields
Forum of Mathematics, Sigma, 2023 We generalize Bloch’s map on torsion cycles from algebraically closed fields to arbitrary fields. While Bloch’s map over algebraically closed fields is injective for zero-cycles and for cycles of codimension at most two, we show that the generalization ...
Theodosis Alexandrou, Stefan Schreieder
doaj +1 more source
, 2014 We introduce a formalism for the geometry of eukaryotic cells and organisms.Cells are taken to be star-convex with good biological reason. This allows for a convenient description of their extent in space as well as all manner of cell surface gradients ...
Morozova, Nadya, Penner, Robert
core +1 more source
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
Nuclear geometry at high energy from exclusive vector meson production [PDF]
, 2022 Heikki Mäntysaari +2 more
openalex +1 more source
Geometry in the Transition from Primary to Post-Primary [PDF]
, 2014 This article is intended as a kind of precursor to the document Geometry for Post-primary School Mathematics, part of the Mathematics Syllabus for Junior Certicate issued by the Irish National Council for Curriculum and Assessment in the context of ...
Barry, Patrick D., O'Farrell, Anthony G.
core +1 more source