Results 71 to 80 of about 3,999,931 (403)

Smart Topology Optimization Using Adaptive Neighborhood Simulated Annealing

open access: yesApplied Sciences, 2021
Topology optimization (TO) of engineering products is an important design task to maximize performance and efficiency, which can be divided into two main categories of gradient-based and non-gradient-based methods.
Hossein R. Najafabadi   +5 more
doaj   +1 more source

Hypercomplex Algebraic Geometry [PDF]

open access: yes, 1998
It is well-known that sums and products of holomorphic functions are holomorphic, and the holomorphic functions on a complex manifold form a commutative algebra over C.
Joyce, Dominic
core   +2 more sources

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

open access: yesFEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin   +2 more
wiley   +1 more source

Effective Geometry

open access: yes, 2003
We introduce the concept of effective geometry by studying several systems in which it arises naturally. As an example of the power and conciseness of the method, it is shown that a flowing dielectric medium with a linear response to an external electric
Bergliaffa, S. E. Perez, Novello, M.
core   +1 more source

Electroweak Vacuum Geometry [PDF]

open access: yes, 1999
We analyse symmetry breaking in the Weinberg-Salam model paying particular attention to the underlying geometry of the theory. In this context we find two natural metrics upon the vacuum manifold: an isotropic metric associated with the scalar sector ...
Kibble, T. W. B., Lepora, Nathan F.
core   +3 more sources

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Unraveling the metastasis‐preventing effect of miR‐200c in vitro and in vivo

open access: yesMolecular Oncology, EarlyView.
Advanced tumors and ineffective cancer treatments can lead to metastases in distant organs. The sole expression of microRNA 200c (miR‐200c) in breast cancer cells is shown to significantly reduce metastasis formation in xenograft mouse models. Various in vitro analyses revealed impeded migratory behavior, upon miR‐200c expression, as one prerequisite ...
Bianca Köhler   +12 more
wiley   +1 more source

The geometry of biological time

open access: yes, 1991
1980 Preface * 1999 Preface * 1999 Acknowledgements * Introduction * 1 Circular Logic * 2 Phase Singularities (Screwy Results of Circular Logic) * 3 The Rules of the Ring * 4 Ring Populations * 5 Getting Off the Ring * 6 Attracting Cycles and Isochrons *
A. Winfree
semanticscholar   +1 more source

Celestial geometry

open access: yesJournal of High Energy Physics, 2022
Abstract Celestial holography expresses $$ \mathcal{S} $$ S -matrix elements as correlators in a CFT living on the night sky. Poincaré invariance imposes additional selection rules on the allowed positions of operators.
Mizera, Sebastian, Pasterski, Sabrina
openaire   +3 more sources

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