Results 51 to 60 of about 528,200 (268)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Weyl metrics and Wiener-Hopf factorization

Journal of High Energy Physics, 2020
We consider the Riemann-Hilbert factorization approach to the construction of Weyl metrics in four space-time dimensions. We present, for the first time, a rigorous proof of the remarkable fact that the canonical Wiener-Hopf factorization of a matrix ...
P. Aniceto, M.C. Câmara, G.L. Cardoso, M. Rosselló   +3 more
doaj   +1 more source

Smart Topology Optimization Using Adaptive Neighborhood Simulated Annealing

Applied Sciences, 2021
Topology optimization (TO) of engineering products is an important design task to maximize performance and efficiency, which can be divided into two main categories of gradient-based and non-gradient-based methods.
Hossein R. Najafabadi, Tiago G. Goto, Mizael S. Falheiro, Thiago C. Martins, Ahmad Barari, Marcos S. G. Tsuzuki   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tight Wavelet Frame Decomposition and Its Application in Image Processing

Journal of Mathematical and Fundamental Sciences, 2013
This paper is devoted to the formulation of a decomposition algorithm using tight wavelet frames, in a multivariate setting. We provide an alternative method for decomposing multivariate functions without accomplishing any tensor product. Furthermore, we
Mahmud Yunus, Hendra Gunawan
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Pseudo-Hyperkähler Geometry and Generalized Kähler Geometry [PDF]

Letters in Mathematical Physics, 2010
We discuss the conditions for additional supersymmetry and twisted supersymmetry in N = (2, 2) supersymmetric non-linear sigma models described by one left and one right semi-chiral superfield and carrying a pair of non-commuting complex structures. Focus is on linear non-manifest transformations of these fields that have an algebra that closes off ...
Göteman, Malin, Lindström, Ulf
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Finite Lattices Generating Not Finitely–Based and Nonstandard Quasivarieties

Journal of Mathematics
There are two well-known and closely related problems in lattice theory: Which finite lattices generate finitely-based quasivarieties? and Which finite lattices generate standard quasivarieties?
M. A. Arapbay, A. O. Basheyeva, S. M. Lutsak   +2 more
doaj   +1 more source