Results 31 to 40 of about 3,161,902 (289)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Multi-View Depth Estimation by Fusing Single-View Depth Probability with Multi-View Geometry [PDF]
, 2021 Gwangbin Bae +2 more
openalex +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Noncommutative geometry and lower dimensional volumes in Riemannian geometry
, 2007 In this paper we explain how to define "lower dimensional'' volumes of any compact Riemannian manifold as the integrals of local Riemannian invariants. For instance we give sense to the area and the length of such a manifold in any dimension.
A. Chamseddine +16 more
core +1 more source
Geometry over composition algebras: Projective geometry
Journal of Algebra, 2006 The purpose of this article is to introduce projective geometry over composition algebras : the equivalent of projective spaces and Grassmannians over them are defined. It will follow from this definition that the projective spaces are in correspondance with Jordan algebras and that the points of a projective space correspond to rank one matrices in ...
openaire +3 more sources
Physics Letters B, 1992 It is shown that, classically, the W-algebras are directly related to the extrinsic geometry of the embedding of two-dimensional manifolds with chiral parametrisation (W-surfaces) into higher dimensional K hler manifolds. We study the local and the global geometries of such embeddings, and connect them to Toda equations.
Gervais, Jean-Loup, Matsuo, Yutaka
openaire +2 more sources
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
, 2008 We reveal the non-metric geometry underlying omega-->0 Brans-Dicke theory by unifying the metric and scalar field into a single geometric structure. Taking this structure seriously as the geometry to which matter universally couples, we show that the ...
Punzi, Raffaele +2 more
core +1 more source
Spinning geometry = Twisted geometry [PDF]
Classical and Quantum Gravity, 2014 22 pages, 5 figures, published ...
Freidel, Laurent, Ziprick, Jonathan
openaire +2 more sources