Results 91 to 100 of about 4,472 (296)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Three hundred thousand years of multi-millennial hydroclimate variability in Northern Africa based on speleothem records from Tunisia

Communications Earth & Environment
Hydroclimate changes in Northern Africa reflect the interplay between mid-latitude westerlies and the West African monsoon, along with their intensity variations.
Yun-Chuan Chung, Hatem Dhaouadi, Gianluca Marino, Emna Sbei, Heikki Seppä, Anu Kaakinen, Mahjoor Ahmad Lone, Hédi Ben Ouezdou, Silvia Frisia, Chuan-Chou Shen   +9 more
doaj   +1 more source

Дунд масштабын геоморфологийн зураг боловсруулах аргазүйн асуудалд

Proceedings of the Mongolian Academy of Sciences, 2017
In order to classify morphology and morphogenetic features of Mongolian eastern region, it is based on the field study measurements, high accurate digital elevation model (DEM), large scale topographical map and targeted to use mapping methodology on ...
Баянжаргал Б, Нямхүү М
doaj   +1 more source

Makers and Users of Geomorphological Maps

, 2011
Abstract In the last 60 years, geomorphology has been recognised as an important field serving several other professions. At the same time there are still limited resources spent on either national or regional geomorphological mapping programmes compared to geological, soil, land cover mapping programmes.
Paron, P., Claessens, L.F.G.
openaire   +3 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Geomorphological mapping in the adjacent area to Syowa Station (abstract)

, 1983
P(論文)Detailed geomorphological mapping in Antarctica is in progress as examplified by the sheet Langhovde 1 : 25,000,near Syowa Station. The information on the geomorphological map is divided into several groups; 1) topography (including contour lines ...
Hirakawa, Kazuomi, Ono, Yugo
core   +1 more source

Segmentation optimization and stratified object-based analysis for semi-automated geomorphological mapping

, 2011
Semi-automated geomorphological mapping techniques are gradually replacing classical techniques due to increasing availability of high-quality digital topographic data.
Anders, N.S., Seijmonsbergen, A.C., Niels S. Anders, Bouten, W., Seijmonsbergen, A.C.; id_orcid, Arie C. Seijmonsbergen, Willem Bouten   +6 more
core   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Multiscale and object-oriented image analysis of high-res LiDAR data for geomorphological mapping in Alpine mountains [PDF]

, 2009
Geomorphological maps are useful to a wide variety of applications, such as hazard risk analysis (Seijmonsbergen 1992), forest ecological research (Van Noord 1996) and geoconservation evaluation studies (Seijmonsbergen et al. in press). Traditional field-
Anders, N.S., Bouten, W., Seijmonsbergen, A.C.; id_orcid, N. S. Anders, A. C. Seijmonsbergen, W. Bouten   +5 more
core  

Geomorphology of the Upper General River Basin, Costa Rica

Journal of Maps, 2019
In spite of the geomorphological diversity of Central America and Costa Rica, there are few detailed geomorphological maps. A 1:25,000 scale map of the Upper General River Basin (UGRB) in Costa Rica is presented, based on the interpretation of aerial ...
Adolfo Quesada-Román, José Juan Zamorano-Orozco   +1 more
doaj   +1 more source