Results 81 to 90 of about 1,177,083 (256)

Three hundred thousand years of multi-millennial hydroclimate variability in Northern Africa based on speleothem records from Tunisia

Communications Earth & Environment
Hydroclimate changes in Northern Africa reflect the interplay between mid-latitude westerlies and the West African monsoon, along with their intensity variations.
Yun-Chuan Chung, Hatem Dhaouadi, Gianluca Marino, Emna Sbei, Heikki Seppä, Anu Kaakinen, Mahjoor Ahmad Lone, Hédi Ben Ouezdou, Silvia Frisia, Chuan-Chou Shen   +9 more
doaj   +1 more source

Geomorphology of sandstone mesas in the Broumovská vrchovina region, NE Czechia

Journal of Maps
Despite their great scientific and tourist importance, sandstone tablelands surprisingly rarely become the subject of geomorphological mapping. Here, we address this research gap by presenting a geomorphological map of Hejda and Ostaš – two of the best ...
Maria Kotowska, Kacper Jancewicz, Piotr Migoń   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Дунд масштабын геоморфологийн зураг боловсруулах аргазүйн асуудалд

Proceedings of the Mongolian Academy of Sciences, 2017
In order to classify morphology and morphogenetic features of Mongolian eastern region, it is based on the field study measurements, high accurate digital elevation model (DEM), large scale topographical map and targeted to use mapping methodology on ...
Баянжаргал Б, Нямхүү М
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Geomorphology of the Upper General River Basin, Costa Rica

Journal of Maps, 2019
In spite of the geomorphological diversity of Central America and Costa Rica, there are few detailed geomorphological maps. A 1:25,000 scale map of the Upper General River Basin (UGRB) in Costa Rica is presented, based on the interpretation of aerial ...
Adolfo Quesada-Román, José Juan Zamorano-Orozco   +1 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Understanding the nature of landslides through detailed geomorphological mapping on the Sumbing Volcanic Landscape, Java Island, Indonesia

Journal of Maps
A 1:2,500-scale geomorphological map was created to illustrate the landslide characteristics on the southern flank of the Sumbing Volcanic Landscape (SVL), Java Island, Indonesia.
Elok Surya Pratiwi, Su-min Shen, Junun Sartohadi   +2 more
doaj   +1 more source