Results 31 to 40 of about 192,260 (184)

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

open access: yesChemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias   +9 more
wiley   +1 more source

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

open access: yesCell Reports, 2018
Summary: Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses.
Christopher J. Ricketts   +769 more
doaj   +1 more source

Dying without Dignity: Homeless Deaths in Los Angeles County: 2000 - 2007 [PDF]

open access: yes, 2007
This report is an investigation into 2,815 homeless deaths in Los Angeles County between January, 2000 and May, 2007, based on statistics provided by the Los Angeles County Coroner's office.
Bob Erlenbusch   +3 more
core  

Evaluating commonly used tools to quantify human activity for protected area management

open access: yesPeople and Nature, EarlyView.
Abstract Recreation in protected areas (PAs) is growing worldwide, potentially conflicting with wildlife and ecosystem protection. Efficiently estimating human activity in PAs is crucial for balancing a dual mandate of supporting visitor access and biodiversity, but managers lack clear recommendations about the conditions under which specific tools are
Alys Granados   +17 more
wiley   +1 more source

The Influence of Managerial Forces and Users’ Judgements on Forecasting in International Manufacturers: a Grounded Study [PDF]

open access: yes, 2015
Despite the improvements in mathematical forecasting techniques, the increase in forecasting accuracy is not yet significant. Previous research discussed various forecasting issues and techniques without paying attention to users’ forces and behaviours ...
Haloub, Radi, Reynolds, Paul Lewis
core  

How digitisation of herbaria reveals the botanical legacy of the First World War

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Digitisation of herbarium collections is bringing greater understanding to bear on the complexity of narratives relating to the First World War and its aftermath – scientific and societal. Plant collecting during the First World War was more widespread than previously understood, contributed to the psychological well‐being of those involved and ...
Christopher Kreuzer, James A. Wearn
wiley   +1 more source

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

open access: yesCell Reports, 2018
Summary: Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven ...
Xinxin Peng   +745 more
doaj   +1 more source

Norman and Nietzsche: The Political Project of Lindsay's The Magic Pudding

open access: yesAustralian Journal of Politics &History, EarlyView.
Australian artist and writer Norman Lindsay (1879–1969) wrote 11 novels and two children's books, one of which—The Magic Pudding first published in 1918—remains a national classic. This article argues that readers and critics have long misunderstood Lindsay's intention in writing this lengthy cartoon‐story about the adventures of Bunyip Bluegum in ...
John Uhr
wiley   +1 more source

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

open access: yesCell Reports, 2018
Summary: Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may respond. The transcriptome of these “hidden responders” may reveal responsive molecular states. We describe and evaluate a
Gregory P. Way   +737 more
doaj   +1 more source

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