Results 41 to 50 of about 3,904 (151)

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

open access: yesCell Reports, 2018
Summary: Protein ubiquitination is a dynamic and reversible process of adding single ubiquitin molecules or various ubiquitin chains to target proteins. Here, using multidimensional omic data of 9,125 tumor samples across 33 cancer types from The Cancer ...
Zhongqi Ge   +740 more
doaj   +1 more source

‘Elbow grease and yellow soap’: Housework time in working‐class households in late‐nineteenth and early twentieth‐century Britain

open access: yesThe Economic History Review, EarlyView.
Abstract Housework is central to feminist calls for recognition of women's work, economic histories explaining the sexual division of labour, and claims regarding the progressive role of scientific knowledge. Yet little is known about the time it actually took. We address this lacuna.
Sara Horrell, Jane Humphries
wiley   +1 more source

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

open access: yesCell Reports, 2018
Summary: Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer.
Michael Seiler   +733 more
doaj   +1 more source

Managing agency business groups, elite directors, and the rubber boom, 1897–1913

open access: yesThe Economic History Review, EarlyView.
Abstract We identify a new organizational form, the Managing Agency Business Group (MABG), demonstrating how agency houses used interlocking directorships to build groups on the basis of commercial and plantation expertise to access finance on London stock markets and local capital markets in the pre‐1914 rubber boom.
David Higgins, Steven Toms
wiley   +1 more source

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

open access: yesCell Reports, 2018
Summary: Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools.
Qingsong Gao   +746 more
doaj   +1 more source

Climate Attribution in Fishery Stock Assessment: Case Studies From the Northeast U.S. Groundfish Stocks

open access: yesFish and Fisheries, EarlyView.
ABSTRACT Climate change poses an unprecedented risk to fisheries ecosystems and economies globally. Ocean warming has led to observed geographic shifts and changes in the productivity of fish stocks. Due to the rapid pace of change in many of the world's oceans, there is a critical need to develop and apply scientific knowledge and tools that can help ...
Lisa A. Kerr   +8 more
wiley   +1 more source

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

open access: yesCell Reports, 2018
Summary: DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types.
Theo A. Knijnenburg   +762 more
doaj   +1 more source

Challenges of integrating sustainability in management education: A 25‐year review of institutional logics, paradoxes and sensemaking

open access: yesInternational Journal of Management Reviews, EarlyView.
Abstract Although sustainability has been championed in management education for over 25 years, its integration remains uneven, fragile and contested. Existing literature mirrors this fragmentation—often descriptive, celebratory or narrowly focused, offering limited insight into the organisational processes that shape integration.
Simona Grande   +3 more
wiley   +1 more source

Creating woodland through natural processes: Current understanding and knowledge gaps in Great Britain

open access: yesEcological Solutions and Evidence
Creating woodlands through natural processes, as opposed to traditional tree planting, is expected to result in more structurally diverse, locally adapted woodlands that enhance the resilience of existing treescapes.
Susannah Fleiss   +30 more
doaj   +1 more source

Systematic Analysis of Splice-Site-Creating Mutations in Cancer

open access: yesCell Reports, 2018
Summary: For the past decade, cancer genomic studies have focused on mutations leading to splice-site disruption, overlooking those having splice-creating potential. Here, we applied a bioinformatic tool, MiSplice, for the large-scale discovery of splice-
Reyka G. Jayasinghe   +750 more
doaj   +1 more source

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