Results 101 to 110 of about 4,489,809 (297)

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Engineering the fitness of older patients for chemotherapy : an exploration of Comprehensive Geriatric Assessment in practice [PDF]

, 2014
Clinicians often report that currently available methods to assess older patients, including standard clinical consultations, do not elicit the information necessary to make an appropriate cancer treatment recommendation for older cancer patients.
Yates, Patsy, Cook, Peta S., McCarthy, Alexandra L., Cook, Peta S   +3 more
core   +3 more sources

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Nationwide Real‐World Modeling of Surgical Outcomes in Elderly Patients: Incorporating Geriatric‐Specific Risk Factors Into Prediction of Mortality and Morbidity

Annals of Gastroenterological Surgery
Aim As the aging population grows, it is crucial to evaluate the quality of surgical care considering geriatric‐specific factors and outcomes. The aim of this study was to develop and validate prediction models for mortality and morbidity in patients ...
Naoya Sato, Hiraku Kumamaru, Mitsukazu Gotoh, Yoshihiro Kakeji, Yuko Kitagawa, Yasuyuki Seto, Hiromi Rakugi, Masahiro Akishita, Kazue Nakajima, Arata Takahashi, Hiroaki Miyata, Shigeru Marubashi   +11 more
doaj   +1 more source

Validation of the Turkish Version of Rapid Geriatric Assessment in Hospitalized Older Adults: A Preliminary Study

Florence Nightingale Journal of Nursing
AIM: Rapid Geriatric Assessment is a practical screening tool for common geriatric syndromes that can be administered in under five minutes, even by inexperienced healthcare professionals.
Sibel Çavdar, Fatma Özge Kayhan Koçak, Batuhan Çakmak, Mert Anıl Altun, Adil Bahadır, Sumru Savaş   +5 more
doaj   +1 more source

Changing Assessment Practice: Process, Principles and Standards [PDF]

, 2008
This is a brief account of what has been learned during the Analysis and Review of Innovations in Assessment (ARIA) project about how changes in assessment practice may be brought about most eff ectively.
Gardner, John, Stobart, Gordon, Harlen, Wynne, Hayward, Louise   +3 more
core  

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

Advanced Science, EarlyView.
A new class of Cu, Ni bimetallic 2D cMOF (CuNi‐HHTP 2D cMOF) featuring dual catalytic sites and high delocalized electronic structure for boosting POD performance. The CuNi‐HHTP 2D‐cMOF enhances the conversion kinetics of H2O2 to ROS, which subsequently enhances antibacterial activity and accelerates the healing of oral ulcers, with macroscopic wound ...
Yixuan Lu, Qinqin Li, Yumin Chen, Shihan Zhang, Shuai Ding, Yanpei Wang, Youxing Liu, Yaru Guo, Xuliang Deng, Shaojun Guo   +9 more
wiley   +1 more source

Incidence and risk factors of Vancomycin-induced thrombocytopenia: a six-year real-world study

BMC Infectious Diseases
Objectives Drug-induced thrombocytopenia has been reported for numerous drugs. Vancomycin-induced thrombocytopenia (VIT) is infrequently and often under-recognized. VIT can lead to the serious consequences of some life-threatening bleeding, especially in
Yuanchao Zhu, Lishuang Huang, Jingjing Zhang, Liang Liang, Pengfei Jin   +4 more
doaj   +1 more source

The added value of geriatric assessment prior to geriatric rehabilitation [PDF]

, 2017
Background: Community dwelling elderly who are temporarily unable to live independently due to functional decline can be referred for geriatric rehabilitation care in a nursing home.
Goos-Peek, N., van Maarschalkerweerd, W. W.A., de Lange, G. D., Diraoui, S. B., de Jonghe, A.   +4 more
core