Results 111 to 120 of about 139,486 (303)

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Libraries of life: Using life history books with depressed care home residents

, 2006
Depression is a common, and often undetected, psychiatric disorder in geriatric care home residents 1,2. Reminiscence, an independent nursing therapy used by a variety of health and social care professionals, can prevent or reduce depression 14.
Plastow, N A
core  

Translation and Validation of the Chinese Version of the Rapid Geriatric Assessment (C-RGA): A Screening Tool for Geriatric Syndromes in Nursing Home Residents

Background: Frailty, sarcopenia, nutritional risk, and cognitive impairment are prevalent geriatric syndromes that adversely affect health outcomes in older adults, underscoring the need for an effective screen tool to enable early detection and timely ...
Roszita Ibrahim, Nor Haty Hassan, Yuezhi Zhu, Jia Liu, Azera Hasra Ismail   +4 more
core   +1 more source

Can Comprehensive Geriatric Assessment Meet Frail Older People’s Needs? Results from the Randomized Controlled Study CGA-Swed

, 2020
Background: The comprehensive geriatric assessment (CGA) designed to manage frail older people requiring acute medical care, is responsible for diagnostics, assessment, treatment, and planning while addressing a person’s medical, psychological ...
Theresa Westgård, Katarina Wilhelmson, Synneve Dahlin-Ivanoff, Isabelle Andersson Hammar   +3 more
core   +1 more source

Comprehensive Geriatric Assessment and Geriatric Interdisciplinary Team Care Model: An Integrated Model for Older Adults

Journal of Multidisciplinary Healthcare
Yinrun Wu, Lei Yang, Yanmei Sha, Yangxin An, Weijuan Li, Xueqin Hu, Gangyu Yang, Xiaoyun Chen Department of Geriatrics, Dali Bai Autonomous Prefecture People’s Hospital, Dali, Yunnan, People’s Republic of ChinaCorrespondence: Xiaoyun Chen, Department of ...
Wu Y, Yang L, Sha Y, An Y, Li W, Hu X, Yang G, Chen X   +7 more
doaj  

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source

Geriatric Helper: An mHealth Application to Support Comprehensive Geriatric Assessment

, 2018
The Comprehensive Geriatric Assessment (CGA) is a multidisciplinary diagnosis approach that considers several dimensions of fragility in older adults to develop an individualized plan to improve their overall health.
Ilídio C. Oliveira, Ilídio C. Oliveira, Samuel Silva, Ilídio Oliveira, Rafael Felgueiras   +4 more
core   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Effectiveness of seven oral traditional Chinese medicines against mild or moderate COVID-19: An updated systematic review and network meta-analysis

Heliyon
Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the outbreak of COVID-19 in Wuhan, China. As a highly infectious epidemic, SARS-CoV-2 rapidly evolves.
Tian Zhang, Ting Li, Fei Zhao, Tongzhou Li, Miaomiao Zhang, Pengfei Jin   +5 more
doaj   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source