Results 131 to 140 of about 5,134,159 (382)

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Educational Games in Geriatric Medicine Education: A Systematic Review [PDF]

, 2010
OBJECTIVE: To systematically review the medical literature to assess the effect of geriatric educational games on the satisfaction, knowledge, beliefs, attitudes and behaviors of health care professionals.
Akl, Elie A., Alfarah, Ziad, Schünemann, Holger J.   +2 more
core   +3 more sources

Modified Frailty Index and Brief Geriatric Assessment do not predict prolonged hospitalization in elderly patients undergoing appendectomy due to Acute Appendicitis

, 2022
Katarzyna Kołodziejska, Piotr Tylec, Jakub Droś, Artur Kacprzyk, Wojciech Kula, Maciej Matyja, Michał Pędziwiatr, Mateusz Rubinkiewicz   +7 more
openalex   +2 more sources

Integrating Comprehensive Geriatric Assessment for people with COPD and frailty starting pulmonary rehabilitation: the Breathe Plus feasibility trial protocol [PDF]

, 2021
Lisa Jane Brighton, Catherine Evans, Morag Farquhar, Katherine Bristowe, Aleksandra Kata, Jade Higman, Margaret Ogden, Claire M. Nolan, Deokhee Yi, Wei Gao, Maria Koulopoulou, Sharmeen Hasan, Claire J. Steves, William D‐C Man, Matthew Maddocks   +14 more
openalex   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Pulse Oximetry as a Fifth Vital Sign in Emergency Geriatric Assessment [PDF]

, 1998
William R. Mower, Gordon B. Myers, Emily L. Nicklin, Kathleen T. Kearin, Larry J. Baraff, Carolyn J. Sachs   +5 more
openalex   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Correlation of geriatric assessment and outcomes of acute myeloid leukemia in elderly patients

Forum of Clinical Oncology
Frailty is a vulnerable susceptibility to stressors during aging. Assessment of frailty could help make appropriate management plans and early interventions.
El Razzaz Mostafa Kamal, Ahmed Tamer Mohamed, Magdy Hebatullah, Dawod Ramadan Eid, Mansour Basma Saeid   +4 more
doaj   +1 more source

Prediction equation for the mini-mental state examination: influence of education, age, and sex

Fisioterapia e Pesquisa, 2019
The mini-mental state examination (MMSE) is a screening test used worldwide for identifying changes in the scope of cognition. Studies have shown the influence of education, age and sex in the MMSE score. However, in Brazil, the studies consider only one
Liliane Patrícia de Souza Mendes, Fernanda Ferreira Malta, Thaís de Oliveira Ennes, Giane Amorim Ribeiro-Samora, Rosângela Corrêa Dias, Bianca Louise Carmona Rocha, Marina Rodrigues, Larissa Faria Borges, Verônica Franco Parreira   +8 more
doaj   +1 more source