Results 51 to 60 of about 229,260 (244)

Diagnostic accuracy of the Ottawa 3DY and Short Blessed Test to detect cognitive dysfunction in geriatric patients presenting to the emergency department [PDF]

, 2018
ObjectivesCognitive dysfunction (CD) is a common finding in geriatric patients presenting to the emergency department (ED). Our primary objective was to determine the diagnostic accuracy of the Ottawa 3DY (O3DY) and Short Blessed Test (SBT) as screening ...
Barbic, David, Barbic, Skye Pamela, Carpenter, Christopher R, Kemplin, Kate, Kim, Brian, Salehmohamed, Qadeem   +5 more
core   +2 more sources

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

An interdisciplinary intervention for older Taiwanese patients after surgery for hip fracture improves health-related quality of life [PDF]

, 2010
Background The effects of intervention programs on health-related quality of life (HRQOL) of patients with hip fracture have not been well studied. We hypothesized that older patients with hip fracture who received our interdisciplinary intervention ...
A Adunsky, AG Randell, AM Moseley, B Samuelsson, CA McHorney, CA McHorney, Chi-Chuan Wu, Council for Economic Planning and Development, Executive Yuan, Republic of China, DB Rubin, DM Bryant, EF Binder, ER Marcantonio, GM Orosz, HM Tseng, Huey-Shinn Cheng, IB Wilson, J Cohen, J Halbert, J Tidermark, J Tidermark, JB Bjorner, JE Ware Jr, Jersey Liang, JL Schafer, JR Lu, JY Tsauo, KW Wyrwich, L Feng, M Crotty, M Weinberger, MC Munin, ME Tinetti, Min-Chi Chen, MJ Liou, P Diaconis, PK Yip, R Perneczky, RA Lyons, RJA Little, S Greenfield, S Hollis, SJ Walters, SK Khan, T Ryan, T von Sternberg, TM Huusko, TT Huang, Yea-Ing L Shyu, YI Shyu, YIL Shyu, YIL Shyu, YIL Shyu, YIL Shyu, YJ Chen, YJ Tsai   +54 more
core   +4 more sources

Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury

Advanced Science, EarlyView.
Dipyridamole acts as a clinically used compound to suppress ferroptosis. Dipyridamole down‐regulates the expression of RNF126, which is an E3 ligase to ubiquitinate SLC7A11 for proteasome degradation. The deficiency of SLC7A11 largely abolishes the protective role of dipyridamole both in vitro and in vivo.
Xiao Zhuang, Shuang Shi, Shuo Liu, Yaqiong Jiao, Bin Huang, Yinghong Yang, Li Yang, Xinquan Yang, Hui Wang, Chunhui Liang, Dandan Song, Huaxiang Yu, Dan Zou, Qi Sun, Shu Yang, Chengqian Yin, Jian Li, Yiming Liu, Junxia Min, Fudi Wang, Yong Nian, Lutao Du, Bo Chu   +22 more
wiley   +1 more source

Glioblastoma in the elderly - how do we choose who to treat? [PDF]

, 2016
Objective: Glioblastoma (GBM) is the commonest primary malignant brain tumour amongst the adult population. Incidence peaks in the 7th and 8th decades of life and as our global population ages, rates are increasing. GBM is an almost universally fatal
Brock, Juliet, Chalmers, Anthony J., Lorimer, Cressida F., Saran, Frank   +3 more
core   +1 more source

Wogonin Attenuates Atherosclerosis via KLF11‐Mediated Suppression of PPARα‐YAP1‐Driven Glycolysis and Enhancement of ABCA1/G1‐Mediated Cholesterol Efflux

Advanced Science, EarlyView.
PPARα promotes KLF11 expression and recruits KLF11 and YAP1 to form a transcription complex, where KLF11 acts as a brake in PPARα‐YAP1‐mediated glycolysis. Wogonin reshapes the metabolism of macrophages from glycolysis to fatty acid oxidation via activation of the PPARα‐KLF11‐YAP1 pathway, by which wogonin reduces inflammation and foam cell formation ...
Chuanrui Ma, Yunqing Hua, Shu Yang, Yun Zhao, Wei Zhang, Yaodong Miao, Jing Zhang, Boxuan Feng, Guobin Zheng, Lan Li, Zhihao Liu, Han Zhang, Mingjun Zhu, Xiumei Gao, Guanwei Fan   +14 more
wiley   +1 more source

Injectable and Sprayable Thermoresponsive Hydrogel with Fouling‐Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions

Advanced Science, EarlyView.
Postoperative cardiac adhesions lead to numerous difficulties in reoperation procedures. Here, a thermo‐responsive in situ formed hydrogel is shown to can reliably cover the wounds after a convenient spraying or injection and significantly reduce adhesion formation in primary and recurrent cardiac injury adhesion models.
Kun Shi, Tao Li, Xulin Hu, Wen Chen, Yan Yu, Zhongwu Bei, Liping Yuan, Qi Tong, Jiafeng Liu, Qiang Fan, Yongjun Qian, Zhiyong Qian   +11 more
wiley   +1 more source

Libraries of life: Using life history books with depressed care home residents [PDF]

, 2006
Depression is a common, and often undetected, psychiatric disorder in geriatric care home residents 1,2. Reminiscence, an independent nursing therapy used by a variety of health and social care professionals, can prevent or reduce depression 14.
Plastow, N A
core   +1 more source

Constructing Polymetallic Nodes in Metal–Organic Frameworks Enhance Antibacterial of Drug‐Resistant Bacteria

Advanced Science, EarlyView.
This work reports a new strategy for constructing multi‐nuclear metal coordination nodes in MOFs for boosting photocatalytic ROS production, which significantly enhances the antibacterial efficiency relative to the MOFs with single‐nuclear metal coordination nodes.
Qinqin Li, Shihan Zhang, Yachao Xu, Yaru Guo, Youxing Liu   +4 more
wiley   +1 more source

A Dual‐Modal Wearable Pulse Detection System Integrated with Deep Learning for High‐Accuracy and Low‐Power Sleep Apnea Monitoring

Advanced Science, EarlyView.
A dual‐modal wearable pulse detection system is developed for sleep apnea monitoring by integrating a self‐powered PENG and PPG sensor with a biomimetic fingertip structure. Through a two‐stage detection strategy, continuous PPW monitoring and on‐demand PPG detection achieve high‐accuracy sleep apnea recognition while maintaining low power consumption.
Jia Wang, Jiangtao Xue, Yang Zou, Yuxin Ma, Junhan Xu, Yanming Li, Fei Deng, Yiqian Wang, Kai Xing, Zhou Li, Tong Zou   +10 more
wiley   +1 more source