Results 121 to 130 of about 283,457 (303)

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

open access: yesAdvanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo   +13 more
wiley   +1 more source

An Initial Study on the Ethical and Moral Standards of Geriatrics Clinical Instructors Construction

open access: yesGuoji laonian yixue zazhi
Objective With the accelerating aging of the global population, the geriatrics has garnered significant attention in recent years. Geriatrics clinical specialty medical students represent a crucial talent pool for this field.
Xu ying, Tao Xinyu, Chen Sen, Qu Chen
doaj   +1 more source

Strategic intelligence monitor on personal health systems phase 3 (SIMPHS3). Integrated care programme for older in- and out-patients University Hospital of Getafe (Spain)., case study report [PDF]

open access: yes, 2015
Abadie, Fabienne   +6 more
core   +1 more source

A qualitative study of older adults' perspectives on initiating exercise and mindfulness practice. [PDF]

open access: yes, 2019
BackgroundMindfulness practice and exercise are ways by which older adults can improve and maintain their physical, emotional and cognitive health.MethodsThis single-site qualitative study gathered insights of older adults' perceptions about initiating ...
Abhishek, Janardan   +5 more
core   +1 more source

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

open access: yesAdvanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang   +17 more
wiley   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

open access: yesAdvanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song   +10 more
wiley   +1 more source

Education and training in geriatrics: guiding the generational change of health professionals

open access: yesGeriatric Care
The increased volume of the aged population, the complexity of patients, and the updates in the legislative aspects linked to older people constitute various challenges for geriatrics.
Liliana Mazza, Lorenzo Palleschi
doaj   +1 more source

Enhancing Elderly Health Through Physical Activities: Insights From a Global Bibliometric Review, 1900–2023

open access: yesAGING MEDICINE, EarlyView.
Bibliometric analysis reveals rising global research on physical activity and elderly health, dominated by developed nations. Key hotspots include healthy aging, physical activity's mental health benefits, and VR exercise interventions. Promoting physical activity is vital for healthy aging, requiring greater technology integration and research from ...
Hongman Wang   +3 more
wiley   +1 more source

National Database of Geriatrics

open access: yesClinical Epidemiology, 2016
Pia Nimann Kannegaard,1 Kirsten L Vinding,2 Helle Hare-Bruun3 1Copenhagen University Hospital, Faculty of Health and Medical Science, Herlev-Gentofte, Geriatric Medical Unit, Capital Region of Denmark, Hellerup, 2Lillebaelt Hospital, Department of ...
Kannegaard PN, Vinding KL, Hare-Bruun H
doaj  

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