Results 141 to 150 of about 293,478 (399)
Advanced Science, EarlyView.This work found that early‐stage insulin sensitization but late‐stage insulin resistance in prenatal caffeine exposure (PCE)‐ induced intrauterine growth restriction (IUGR) offspring may be related to the hepatic AGEs accumulation via intrauterine GR/miR‐1224 programming by glucocorticoids.
Yongguo Dai +5 more
wiley +1 more source
Advanced Science, EarlyView.Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu +15 more
wiley +1 more source
National Database of Geriatrics
Clinical Epidemiology, 2016 Pia Nimann Kannegaard,1 Kirsten L Vinding,2 Helle Hare-Bruun3 1Copenhagen University Hospital, Faculty of Health and Medical Science, Herlev-Gentofte, Geriatric Medical Unit, Capital Region of Denmark, Hellerup, 2Lillebaelt Hospital, Department of ...
Kannegaard PN, Vinding KL, Hare-Bruun H
doaj
Advanced Science, EarlyView.This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou +10 more
wiley +1 more source
The clinical method in geriatrics
Medisur, 2010 Population aging and the distinctive characteristics of elderly require a particular implementation of the clinical method. Taking into account the special health problems of elderly, the geriatric evaluation is the cornerstone for the medical attention ...
Ángel Julio Romero Cabrera +1 more
doaj +2 more sources
MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
Advanced Science, EarlyView.This study uncovers a size‐dependent adhesion paradigm, demonstrating that the glycocalyx protein MUC15 suppresses pancreatic cancer progression by attenuating integrin activation, focal adhesion assembly, and YAP mechanotransduction. Integrating computational modeling and experimental validation, the work reveals a mechanical mechanism by which MUC15 ...
Simei Zhang +18 more
wiley +1 more source
National Blueprint: Increasing Physical Activity Among Adults Age 50 and Older [PDF]
, 2001 Outlines a variety of approaches for organizations, associations, and agencies to plan strategies to help people age 50 and older increase their physical ...
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Sālmand, 2016 Objectives: The database and the journals indexed under them are the most important information resources for students and experts in various disciplines, including geriatrics.
Mansoureh Feizabadi +2 more
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The Mechanism and Potential Therapeutic Strategies of Vascular Aging
AGING MEDICINE, EarlyView.The phenotypes of vascular aging vary across different blood vessels. Endothelial dysfunction is observable in the endothelium of all vessels, while vascular structural remodeling primarily occurs in arteries. A decline in organ vascular density mainly affects arterioles, venules, and capillaries, whereas thrombosis predominantly occurs in the ...
Wan‐Zhou Wu +4 more
wiley +1 more source