Results 131 to 140 of about 90,557 (301)

Characterization of a novel breast carcinoma xenograft and cell line derived from a BRCA1 germ-line mutation carrier

, 2003
A human tumor xenograft (L56Br-X1) was established from a breast cancer axillary lymph node metastasis of a 53-year-old woman with a BRCA1 germ-line nonsense mutation (1806C>T; Q563X), and a cell line (L56Br-C1) was subsequently derived from the ...
Kytöla, Soili, Kjellén, Elisabeth,, Gudjonsson, Thorarinn, Oredsson, Stina,, Olsson, Håkan,, Isola, Jorma,, Borg, Ake, Hedenfalk, Ingrid A,, Vallon-Christersson, Johan,, Wennerberg, Johan,, Petersen, Ole W, Johannsson, Oskar T,, Staff, Synnöve, Rennstam, Karin,, Lund University., Adeyinka, Adewale,, Baldetorp, Bo,   +16 more
core   +2 more sources

Generation of an isogenic iPSC line via CRISPR correction of the POMC:W84X mutation for monogenic obesity modeling

Stem Cell Research
We report the generation of a genetically corrected induced pluripotent stem cell (iPSC) line, BIHi261-A-1, derived from the patient-specific iPSC line BIHi261-A carrying a homozygous truncating mutation in the POMC gene (POMC:W84X). This mutation causes
Katarzyna A. Ludwik, Valeria Fernandez Valone, Regina Jahn, Sabine Jyrch, Lara Lechner, Peter Kühnen, Harald Stachelscheid   +6 more
doaj   +1 more source

Supplementary Figure Legends 1-3 from A Novel Breast Cancer–Associated BRIP1 (FANCJ/BACH1) Germ-line Mutation Impairs Protein Stability and Function

, 2008
Supplementary Figure Legends 1-3 from A Novel Breast Cancer–Associated BRIP1 (FANCJ/BACH1) Germ-line Mutation Impairs Protein Stability and ...
Generoso Bevilacqua (238052), Ronny Drapkin (130800), Serena Barbuti (14973888), Mariella Tancredi (3405317), Cristina Chantal Flemma (14973885), Arcangela De Nicolo (14891898), Grazia Lombardi (196657), Claudio Di Cristofano (6648347), Bijan Sobhian (14973891), Maria Adelaide Caligo (5768024)   +9 more
core   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, EarlyView.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Highly variable recessive lethal or nearly lethal mutation rates during germ-line development of male Drosophila melanogaster

, 2011
Each cell of higher organism adults is derived from a fertilized egg through a series of divisions, during which mutations can occur. Both the rate and timing of mutations can have profound impacts on both the individual and the population ...
Yun-Xin Fu, Jing Hu, Pan, Xue-Rong, Wu, Jian-Min, Xue-Rong Pan, Woodruff, Ronny C, Gao, Jian-Jun, Shao, Ye-Lin, Li Ma, Fu, Yun-Xin, Barton, Sara A, Jian-Min Wu, Hu, Jing, Ronny C. Woodruff, Ma, Li, Ye-Lin Shao, Sara A. Barton, Zhang, Ya-Ping, Ya-Ping Zhang, Jian-Jun Gao   +19 more
core   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Kif18a is specifically required for mitotic progression during germ line development.

, 2015
Genome integrity in the developing germ line is strictly required for fecundity. In proliferating somatic cells and in germ cells, there are mitotic checkpoint mechanisms that ensure accurate chromosome segregation and euploidy. There is growing evidence
Byers, Candice, Czechanski, Anne M, Stumpff, Jason, Reinholdt, Laura G, Kim, Haein, Greenstein, Ian   +5 more
core   +1 more source

The human germ cell lineage: pluripotency, tumourigenesis and proliferation

, 2008
EThOS - Electronic Theses Online ServiceGBUnited ...
Perrett, Rebecca Mary
core