Results 141 to 150 of about 64,503 (262)

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.

Blood, 2014
Manchev VT, Hilpert M, Berrou E, Elaib Z, Aouba A, Boukour S, Souquere S, Pierron G, Rameau P, Andrews R, Lanza F, Bobe R, Vainchenker W, Rosa JP, Bryckaert M, Debili N, Favier R, Raslova H.   +17 more
europepmc   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Characteristics associated with clinical response to pomalidomide in hereditary hemorrhagic telangiectasia. [PDF]

Blood Adv
Al-Samkari H, Thomas SM, Marsh D, Kasthuri RS, Iyer VN, Pishko AM, Decker JE, Weiss CR, Whitehead KJ, Conrad MB, Zumberg MS, Zhou JY, Parambil J, Carper B, Clancy M, McCrae KR.   +15 more
europepmc   +1 more source

Within genome variation of germ-line and somatic mutation

, 2017
Variation in the mutation rate along the human genome, if not properly understood and accounted\ud for, has the potential to confound evolutionary studies, produce spurious driver candidates in cancer\ud studies, and hinder the diagnostics aimed at understanding the etiologies of genetic diseases.\ud \ud In this thesis I consider mutation rate ...
openaire  

Bilateral Prophylactic and Contralateral Risk‐Reducing Mastectomy in Women With Germline CDH1 Pathogenic or Likely‐Pathogenic Variants

Journal of Surgical Oncology, EarlyView.
ABSTRACT Bilateral prophylactic mastectomy (BPM) or contralateral risk‐reducing mastectomy (CRRM) are considered in CDH1 carriers as a strategy to reduce lobular breast cancer (LBC) risk in women. In this study we aimed to evaluate the overall number of these procedures reported in literature.
Giovanni Corso, Carlo La Vecchia, Francesca Magnoni, Andrea Polizzi, Elisa Bottazzoli, Alessandra De Scalzi, Susanna Di Silvestre, Eleonora Meduri, Filippo Pesapane, Luca Nicosia, Francesca De Lorenzi, Mattia Intra, Viviana Galimberti, Paolo Veronesi   +13 more
wiley   +1 more source

Cathepsin B protease mediates high population density-induced mutagenesis to drive genome evolution and competitive growth. [PDF]

Nat Commun
Yu B, Suehiro Y, Johnson BJ, Lee ES, Li D, Huang Y, Johnson J, Ou G, DeGregori J, Mitani S, Xue D.   +10 more
europepmc   +1 more source

Myasthenia Gravis and Thymoma

Muscle &Nerve, EarlyView.
ABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Benjamin Claytor, Lukas Delasos, Daniel P. Raymond, Erik Seroogy, Jason Lempel, Yuebing Li   +5 more
wiley   +1 more source

On the potential origin of the zygote-like cancer stem cell with a focus on fusion for cell rescue. [PDF]

Front Cell Dev Biol
Cismaru CA, Chira S, Calin GA, Netea-Maier R, Berindan-Neagoe I.   +4 more
europepmc   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source