Results 181 to 190 of about 90,557 (301)

Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer

The Journal of Pathology, EarlyView.
Abstract Recently, we suggested the combination of chemotherapy and P2RX4 inhibition as a promising novel therapeutic approach for P2RX4‐expressing epithelial tumors to prevent paracrine resistance. Here, we aimed to assess whether determining P2RX4 expression status in colorectal and pancreatic cancer patients would allow stratification of potentially
Christoph Steup, Julian Dosch, Christopher Dietz‐Fricke, Sara Khosraviseftejani, Esther Engel, Adalbert F de Valk, Dominic Menger, Patrick Welker, Peter J Wild, Kilian B Kennel, Maja Kantlehner, Paul K Ziegler, Florian R Greten   +12 more
wiley   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.

Blood, 2014
Manchev VT, Hilpert M, Berrou E, Elaib Z, Aouba A, Boukour S, Souquere S, Pierron G, Rameau P, Andrews R, Lanza F, Bobe R, Vainchenker W, Rosa JP, Bryckaert M, Debili N, Favier R, Raslova H.   +17 more
europepmc   +1 more source

From wild to tamed: Reimagining novel crops through omics and local plant diversity

PLANTS, PEOPLE, PLANET, EarlyView.
The global food system faces growing pressure from climate change, biodiversity loss, and rising nutritional demands. Agriculture has increased yields but reduced crop diversity, flavor, and nutritional quality, leaving societies vulnerable and dependent on a narrow set of staple species.
Alexandra Sanfeliu Meliá, Pablo D. Cárdenas   +1 more
wiley   +1 more source

Origins of Self-Fertility in Three <i>Caenorhabditis</i> Nematodes. [PDF]

Biology (Basel)
Bobinski M, Kennedy J, Pilgrim D, Ellis RE.   +3 more
europepmc   +1 more source

Temporal dynamics of co‐inoculation of Leptosphaeria maculans and Leptosphaeria biglobosa determine interspecific competition and disease development on oilseed rape

Pest Management Science, EarlyView.
This study provides evidence that the timing of co‐inoculation of Leptosphaeria maculans and Leptosphaeria biglobosa determine the outcome of interspecific competition and disease development on their host oilseed rape. Abstract BACKGROUND Phoma stem canker is one of the most economically damaging diseases of oilseed rape, caused by co‐existing fungal ...
Evren Bingol, Chinthani S. Karandeni Dewage, Aiming Qi, Faye Ritchie, Bruce DL Fitt, Yong‐Ju Huang   +5 more
wiley   +1 more source

FLT3 as a germ line driver in AML: expanding the landscape of leukemia predisposition. [PDF]

Blood Neoplasia
Swaroop A, Johnson NL, Tophkhane MC, Rodgers C, Pogrebetskaya M, Koppayi A, Dominguez S, Padron E, Altman JK, Godley LA.   +9 more
europepmc   +1 more source

Resistance of Botrytis cinerea to anilinopyrimidine fungicides: A novel ARMS‐PCR method for the detection of Bcpos5 mutations and characterization of resistance using CRISPR/Cas9 editing

Pest Management Science, EarlyView.
A TETRA‐primer amplification refractory mutation system polymerase chain reaction (T‐ARMS‐PCR) method was developed for simultaneous detection of the L412F/V and G408V mutations. L412F/V mutants were created using the CRISPR/Cas tool and no fitness cost was observed.
Georgios Sofianos, Athanasios Petmezas, Anastasios Samaras, George Karaoglanidis   +3 more
wiley   +1 more source

Correction: Germ-line exon 21 EGFR V831H mutation in advanced NSCLC resistance to almonertinib: a case report. [PDF]

Front Oncol
Cai D, Lou J, Zhu Y, Wang Y.
europepmc   +1 more source

Disease control in oilseed rape: Current insights and perspectives for next‐generation integrated pest management

Pest Management Science, EarlyView.
Winter oilseed rape in Europe suffers frequent pathogen losses. This review outlines key integrated pest management (IPM) strategies, rotation, residue and tillage management, optimized sowing, resistance, and targeted fungicides supported by forecasting.
Jon S West, Małgorzata Jędryczka, Nazanin Zamani‐Noor   +2 more
wiley   +1 more source