Results 201 to 210 of about 64,503 (262)

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Discrete 3' UTR sequence motifs regulate nanos RNA enrichment in Drosophila germ granules. [PDF]

Dev Biol
Mitchel K, Gavis ER.
europepmc   +1 more source

Collagen Type VI Alpha 1 as a Regulator of Redox Homeostasis in Antioxidant‐Enhanced Osteogenesis of Dental Stem Cells

Cell Proliferation, EarlyView.
Under physiological conditions, NAC activates the PI3K‐AKT‐COL6A1 axis to sustain redox balance and enhance osteogenesis. COL6A1 deficiency, however, compromises this axis, inducing oxidative stress and impairing NAC's osteogenic efficacy. ABSTRACT Alveolar bone injury represents a prevalent clinical challenge in dentistry, for which stem cell‐based ...
Zhaosong Meng, Jiacheng Liu, Yue Zhang, Ruimeng Yang, Jingyi Zhang, Haosun Yang, Zheng Wang, Ran Wei, Zhe Li, Shuling Guo, Lizhi Hu, Lei Sui   +11 more
wiley   +1 more source

A patient-derived CABIN1 mutation recapitulates features of idiopathic multicentric Castleman disease in a mouse model. [PDF]

Blood Adv
Laczko D, Tsao P, Pai RA, Zinski J, Gonzalez MV, Mumau MD, Raabe T, Muramatsu H, Pardi N, Kambayashi T, Fajgenbaum DC.   +10 more
europepmc   +1 more source

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

TNFSF10: a promising prognostic biomarker and therapeutic target for immunotherapy in testicular germ cell tumors. [PDF]

Front Immunol
Liu G, Du L, Lv S, Liu Z, Cao J, Fan L, Zhang S, Xu K, Xue L.   +8 more
europepmc   +1 more source

A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance

Cell Proliferation, EarlyView.
SENP8 regulates a non‐canonical NEDD8‐dependent pathway to stabilize STAT1, promote CCL2/CCL5 transcription, and maintain germ cell proliferation and migration.
Meng Liu, Xiya Qiu, Wenying Qu, Yue Ma, Mingyuan Bao, Yuxuan Feng, Xiaochu Wang, Tao Zhou, Bo Zheng, Shunyu Hou, Yu Xia, Qingxia Meng   +11 more
wiley   +1 more source

Mouse germline cysts contain a fusome-like structure that mediates oocyte development. [PDF]

Elife
Pathak M, Spradling AC.
europepmc   +1 more source

The pos-1 3' untranslated region governs germline specification and proliferation to ensure reproductive robustness. [PDF]

PLoS Genet
Varderesian HV, Utaegbulam JN, Brown HE, Ramirez B, Velcani M, Ryder SP.   +5 more
europepmc   +1 more source

Role of KIT signaling in ovarian development and function: insights from multisystem biology†. [PDF]

Biol Reprod
So W, Pak AE, Abazarikia A, Chemerinski A, Douglas NC, Kim SY.   +5 more
europepmc   +1 more source