Results 221 to 230 of about 90,557 (301)

Impact of the CYFIP2 R87C variant in a human neuronal model in vitro. [PDF]

Sci Rep
Zaboroski-Silva I, da Silva Brandão E, de Freitas Brenha B, Landry C, Carrara J, Ferreira RS, Vaz IM, Jamur VR, Schaffer AE, Miranda HC, Shigunov P.   +10 more
europepmc   +1 more source

Extinction risk by mutational meltdown [PDF]

, 1994
Loeschcke, Volker, Bürger, Reinhard, Gabriel, Wilfried   +2 more
core  

Testis‐Enriched F‐Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice

Andrology, EarlyView.
ABSTRACT Background The SCF (Skp–Cullin–F‐box) complex is a major class of E3 ubiquitin ligases. F‐box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F‐box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes.
Yuki Kaneda, Haruhiko Miyata, Masahito Ikawa   +2 more
wiley   +1 more source

Multiple ShKT domain-containing MUL-1 proteins act as redox-responsive modulators of oxidative stress signaling in C. elegans. [PDF]

Mol Cells
Carranza-García E, Santos AG, Yoon KH, Gartner A.   +3 more
europepmc   +1 more source

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

The <i>Caenorhabditis</i> Gli protein TRA-1 makes a transcriptional activator that promotes spermatogenesis. [PDF]

iScience
Shen Y, Lin SY, Guo Y, Imtiaz J, Corley K, Ellis RE.   +5 more
europepmc   +1 more source

Detection of Germ Line p53 Mutations in Hereditary Cancer

Clinical Chemistry, 1992
openaire   +1 more source

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

Germline Predisposition in Pediatric Central Nervous System Tumors: Insights from a Multigene Panel Study. [PDF]

Oncol Res
Park M, Park S, Oh E, Choi J, Kwon MM, Park SY, Lee JA, Park HJ.   +7 more
europepmc   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source