Results 241 to 250 of about 90,557 (301)

Role of KIT signaling in ovarian development and function: insights from multisystem biology†. [PDF]

Biol Reprod
So W, Pak AE, Abazarikia A, Chemerinski A, Douglas NC, Kim SY.   +5 more
europepmc   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Mouse germline cysts contain a fusome-like structure that mediates oocyte development. [PDF]

Elife
Pathak M, Spradling AC.
europepmc   +1 more source

Tumor‐Derived Exosomal piR‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer

Cancer Science, EarlyView.
Breast cancer–derived exosomal piR‐hsa‐28212 promotes lymphangiogenesis and lymph node metastasis by activating VEGFC/VEGFR3 signaling. It stabilizes TBX1 mRNA in lymphatic endothelial cells and METTL3 protein in tumor cells, enhancing VEGFR3 expression and VEGFC secretion.
Yafen Wang, Tianli Zhang, Xue Kong, Yao Tong, Yanru Li, Xiangjun Dong, Chuanxin Wang, Juan Li   +7 more
wiley   +1 more source

Update of germ line RUNX1 variant curation rules: version 3.1. [PDF]

Blood Adv
Hattig Z, Carlelycke TE, Ruiz Martin A, Walker T, Speck NA, Liu P, Wu D, Godley LA.   +7 more
europepmc   +1 more source

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, EarlyView.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

A patient-derived CABIN1 mutation recapitulates features of idiopathic multicentric Castleman disease in a mouse model. [PDF]

Blood Adv
Laczko D, Tsao P, Pai RA, Zinski J, Gonzalez MV, Mumau MD, Raabe T, Muramatsu H, Pardi N, Kambayashi T, Fajgenbaum DC.   +10 more
europepmc   +1 more source

Genetic and functional characterization of AMH Signaling in Zebrafish - Evidence for Roles of Amh-Bmpr2a-Bmpr1bb Pathway in Controlling Gonadal Homeostasis. [PDF]

PLoS Genet
Yue Y, Zeng C, Zhang X, Bian C, Zhang Z, Wu K, Chen W, Zhou X, Lu L, Ai N, Ge W.   +10 more
europepmc   +1 more source

Case Report: A rare case of synchronous ovarian mixed germ cell tumor and mast cell leukemia in a pediatric patient. [PDF]

Front Oncol
Liu C, Chu J, Wan Y, Wang H, Yu H, Zhang K, Xie Z, Tu S, Wang N, Yang L.   +9 more
europepmc   +1 more source

Diagnostic sequencing identifies high-risk markers and mechanisms of resistance to guide immunotherapy selection. [PDF]

Blood Adv
Sudha P, Pham P, Niu W, Liu E, Wang L, Truong G, Ligocki C, Al-Azzawi R, Surapenini M, Bray SM, Vetrini F, Czader M, Tayeh MK, Lee K, Abonour R, Suvannasankha A, Walker BA.   +16 more
europepmc   +1 more source