Results 251 to 260 of about 135,756 (330)

Mouse genome engineering uncovers 18 genes dispensable for male reproduction

Andrology, EarlyView.
Abstract Background Male infertility is an intricate multifactorial disease involving the interplay between genetic and environmental factors. Genetic anomalies account for more than 15% of all male infertility cases; however, diagnosing them exhibits enormous challenges due to variable symptomatic presentations and limited knowledge of gene functions.
Hsin‐Yi Chang, Yonggang Lu, Kaito Yamamoto, Jiang Sun, Keisuke Shimada, Yuki Hiradate, Yoshitaka Fujihara, Masahito Ikawa   +7 more
wiley   +1 more source

Endogenous Processes Underlying Clock-Like Mutational Signatures. [PDF]

Genes Chromosomes Cancer
Druck T, Aqeilan RI, Aldaz CM, Zanesi N, Huebner K.   +4 more
europepmc   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis. [PDF]

PLoS Genet
Xie Q, Wu H, Qiu J, Liu J, Jiang X, Wu H, Lyu Q, Long H, Li W, Zhang S, Zhou Y, Gao Y, Hsueh AJW, Kuang Y, Suo L.   +14 more
europepmc   +1 more source

Seminal Plasma Exosomal miRNA Profiling Reveals hsa‐miR‐7‐5p as a Key Regulator of Sperm Motility in Asthenozoospermia

Andrology, EarlyView.
ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu, Meng‐Li Cui, Wen‐Jing Yuan, Jia‐Ning Zhang, Shuo Zhang, Xi‐Qiao Yao, Ruo‐Qing Li, Jin‐Feng Li, En‐Zhong Li   +8 more
wiley   +1 more source

BRCA1/2 impact on the development of implant-associated lymphoma in women with breast cancer and textured implants. [PDF]

Blood Adv
Ghione P, Mandelker D, Arcila M, Seshan V, Terry MB, Vijai J, Cordeiro P, Vanderbilt C, Pressley J, Chan A, Galasso N, Dogan A, Salles G, de Jong D, van Leeuwen F, Horwitz S.   +15 more
europepmc   +1 more source

Sperm Sexing in Selected Animals and Humans: Methods, Applications, and Future Prospects

Andrology, EarlyView.
ABSTRACT Background Sperm sexing is a technique that enables the selection of offspring sex by sorting spermatozoa based on their sex chromosomes. This technology has gained increasing attention due to its potential applications in both animal breeding and human‐assisted reproduction.
Domrazek Kinga, Jurka Piotr
wiley   +1 more source

Dynamics of circulating tumour DNA in relapsed/refractory diffuse large B‐cell lymphoma patients

British Journal of Haematology, EarlyView.
Summary The response to salvage chemotherapy in relapsed/refractory (R/R) diffuse large B‐cell lymphoma (DLBCL) is poor, and data on circulating tumour deoxyribonucleic acid (ctDNA) in this setting are limited. We evaluated ctDNA dynamics in 29 patients with relapsed or refractory DLBCL who received platinum‐based salvage chemotherapy at the University
Yujie Zhong, Johanna Bult, Nick Veltmaat, Filipe Montes de Jesus, Laurens Sillje, Joost Kluiver, Anke van den Berg, Wouter Plattel, Arjan Diepstra, Marcel Nijland   +9 more
wiley   +1 more source

Cannonball metastases as an initial presentation of urothelial bladder carcinoma: a case report and literature review. [PDF]

Urol Case Rep
Rayapureddi K, Glover M, Guo HH, Chan E, Shah SA.   +4 more
europepmc   +1 more source

Renal cell carcinoma with a novel germ-line mutation in isocitrate dehydrogenase 1 (IDH1) and its functional study.

, 2013
Tatsuya Takayama, Mitsuhiro Kitagawa, Naohisa Takaoka, Naoyuki Sugiyama, Kaori Igarashi, Miki Miyazaki, Takayuki Sugiyama, Fumitake Kai, Tomoyoshi Soga, Seiichiro Ozono   +9 more
openalex   +1 more source