Results 261 to 270 of about 135,756 (330)

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

The NANOS RNA-binding protein variants: a model for understanding human infertility. [PDF]

J Appl Genet
Kunik A, Lakshmi B, Jaruzelska J, Kusz-Zamelczyk K.   +3 more
europepmc   +1 more source

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao, Sinan Ai, Yaoxian Wang, Yuning Liu, Jingwei Zhou, Qingqing Liu, Xu Wang, Danting Li, Xin Li, Lin Wang, Jinyi Hou, Liang Peng, Zhen Wang   +12 more
wiley   +1 more source

Reactivation of Human X-Linked Gene and Stable X-Chromosome Inactivation Observed in Generation and Differentiation of iPSCs from a Female Patient with HNRNPH2 Mutation. [PDF]

Cells
Chen G, Rodriguez-Lopez A, Wangsa D, Lomash RM, Huang X, Chen CZ, Bowling RA, Ghousifam N, Banks CJ, Hurd KA, Zou J, Zheng W.   +11 more
europepmc   +1 more source

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, EarlyView.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source

Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients harbouring TTN mutations. [PDF]

Stem Cell Res
Tan R, Chen YI, Zha Y, Herron T, Haddad F, Sallam K, Wu JC.   +6 more
europepmc   +1 more source

A Patient with an Extra-adrenal Pheochromocytoma and Germ-line <i>SDHB</i> Mutation Accompanied by an Atypical Meningioma

, 2015
Tsuguka Shiwa, Kenji Oki, Masayasu Yoneda, Koji Arihiro, Haruya Ohno, Rui Kishimoto, Nobuoki Kohno   +6 more
openalex   +2 more sources

Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents

Cell Proliferation, EarlyView.
Our study (1) represented a first systematic analysis of species‐specific adaptation in the DNA binding pattern of transcription factor; (2) represented a first study of cis‐regulation between two reproductively isolated species by using a novel allodiploid system; (3) demonstrated a higher conservation of transcriptional output than that of DNA ...
Weizheng Liang, Guipeng Li, Yukai Wang, Wencheng Wei, Rui Chen, Siyue Sun, Diwen Gan, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Huanhuan Cui, Wei Chen   +13 more
wiley   +1 more source

DNA methylation dictates histone modifications in developing male germ cells in the mouse. [PDF]

Nucleic Acids Res
Sugimoto H, Kawase M, Ichiyanagi K.
europepmc   +1 more source

Kdf1 Regulates Molar Cusp Morphogenesis via the PI3K/AKT/mTOR Signalling Axis

Cell Proliferation, EarlyView.
Epithelial Kdf1 knockout disrupts molar cusp morphogenesis by promoting inner enamel epithelium proliferation and invagination via PI3K/AKT/mTOR signalling. ABSTRACT Keratinocyte differentiation factor 1 (Kdf1) reportedly plays a significant role in enamel formation.
Jiayu Wang, Miao Yu, Hangbo Liu, Kai Sun, Chenxin Geng, Haochen Liu, Hailan Feng, Yang Liu, Hu Zhao, Dong Han   +9 more
wiley   +1 more source