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Embryonic Germ Cells: When Germ Cells Become Stem Cells
Seminars in Reproductive Medicine, 2006Embryonic germ cells (EGCs) are pluripotent stem cells derived from primordial germ cells (PGCs). PGCs are progenitors of adult gametes, which diverge from the somatic lineage between late embryonic to early fetal development. First derived in the mouse, EGCs have also been derived from human, chicken, and pig.
Candace L, Kerr +3 more
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Clinics in Obstetrics and Gynaecology, 1983
Germ cell tumours of the ovary are the most common ovarian cancer in women who are 20 years of age or less. Successful treatment of early stage disease is available. Proper management requires strict adherence to the guidelines set forth. Failure to properly identify the elements present in a tumour, perform the correct surgical procedure, or render ...
C R, Stanhope, J P, Smith
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Germ cell tumours of the ovary are the most common ovarian cancer in women who are 20 years of age or less. Successful treatment of early stage disease is available. Proper management requires strict adherence to the guidelines set forth. Failure to properly identify the elements present in a tumour, perform the correct surgical procedure, or render ...
C R, Stanhope, J P, Smith
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Science China Life Sciences, 2010
Fish, like many other animals, have two major cell lineages, namely the germline and soma. The germ-soma separation is one of the earliest events of embryonic development. Germ cells can be specifically labeled and isolated for culture and transplantation, providing tools for reproduction of endangered species in close relatives, such as surrogate ...
Xu, H.Y. +3 more
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Fish, like many other animals, have two major cell lineages, namely the germline and soma. The germ-soma separation is one of the earliest events of embryonic development. Germ cells can be specifically labeled and isolated for culture and transplantation, providing tools for reproduction of endangered species in close relatives, such as surrogate ...
Xu, H.Y. +3 more
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Hematology/Oncology Clinics of North America, 1992
The development of modern surgical staging and effective chemotherapy regimens has markedly improved outcome of treatment of ovarian germ cell tumors. Almost all patients with completely resected tumors will survive their disease. Those with tumors other than dysgerminoma should all receive adjuvant chemotherapy. Patients with stage IA dysgerminoma can
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The development of modern surgical staging and effective chemotherapy regimens has markedly improved outcome of treatment of ovarian germ cell tumors. Almost all patients with completely resected tumors will survive their disease. Those with tumors other than dysgerminoma should all receive adjuvant chemotherapy. Patients with stage IA dysgerminoma can
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New England Journal of Medicine, 2007
Testicular cancer is rare, accounting for 1% to 2% of all male malignancies. Nearly 90% to 95% of tumors arising in testis are germ cell in origin. Other sites of malignant germ cell tumors include the retroperitoneum, mediastinum, sacrococcygeal region, and pineal gland. The highest incidence is seen in Scandinavian countries, particularly Denmark (1).
De Giorgi U, Pedrazzoli P, Rosti G
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Testicular cancer is rare, accounting for 1% to 2% of all male malignancies. Nearly 90% to 95% of tumors arising in testis are germ cell in origin. Other sites of malignant germ cell tumors include the retroperitoneum, mediastinum, sacrococcygeal region, and pineal gland. The highest incidence is seen in Scandinavian countries, particularly Denmark (1).
De Giorgi U, Pedrazzoli P, Rosti G
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Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1995
Whether germ cells succeed in making eggs or sperm depends both on their genetic constitution and on the tissue environment in which they develop. The decision as to whether it is oogenesis or spermatogenesis on which they initially embark depends only on their environment, however, and not at all on their own chromosomes.
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Whether germ cells succeed in making eggs or sperm depends both on their genetic constitution and on the tissue environment in which they develop. The decision as to whether it is oogenesis or spermatogenesis on which they initially embark depends only on their environment, however, and not at all on their own chromosomes.
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Annals of Internal Medicine, 1981
Excerpt To the editor: The letters by Page (1) and Newcomer (2) in the May issue and the comments by other physicians in response to our article on unrecognized germ cell cancers (3) warrant a repl...
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Excerpt To the editor: The letters by Page (1) and Newcomer (2) in the May issue and the comments by other physicians in response to our article on unrecognized germ cell cancers (3) warrant a repl...
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2019
Germ cells undergo epigenome reprogramming for proper development of the next generation. The achievement of in vitro germ cell derivation from human and mouse pluripotent stem cells and further differentiation in a plane culture and in aggregation with gonadal somatic cells offers unprecedented opportunities for investigation of the germ cell ...
Kazuki, Kurimoto, Mitinori, Saitou
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Germ cells undergo epigenome reprogramming for proper development of the next generation. The achievement of in vitro germ cell derivation from human and mouse pluripotent stem cells and further differentiation in a plane culture and in aggregation with gonadal somatic cells offers unprecedented opportunities for investigation of the germ cell ...
Kazuki, Kurimoto, Mitinori, Saitou
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Seminars in Reproductive Medicine, 2005
Transplantation of male germ line stem cells from a fertile donor to the testis of an infertile recipient restores donor-derived spermatogenesis in the recipient testis. The resulting sperm pass the donor genotype to the offspring of the recipient. Germ cell transplantation helped to elucidate the biology of male germ line stem cells and their niche in
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Transplantation of male germ line stem cells from a fertile donor to the testis of an infertile recipient restores donor-derived spermatogenesis in the recipient testis. The resulting sperm pass the donor genotype to the offspring of the recipient. Germ cell transplantation helped to elucidate the biology of male germ line stem cells and their niche in
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Seminars in Diagnostic Pathology, 2005
Germ Cell Tumors (GCT) represent an important group of mediastinal tumors. Because of genetic characteristics and behavior have been divided in prepubertal and postpubertal tumors, and their origin remains controversial. The genetic changes are diverse, but the most frequent is i (12p), and can be associated to gonadal disgenesis.
Hugo, Domínguez Malagón +1 more
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Germ Cell Tumors (GCT) represent an important group of mediastinal tumors. Because of genetic characteristics and behavior have been divided in prepubertal and postpubertal tumors, and their origin remains controversial. The genetic changes are diverse, but the most frequent is i (12p), and can be associated to gonadal disgenesis.
Hugo, Domínguez Malagón +1 more
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