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Science China Life Sciences, 2010 Fish, like many other animals, have two major cell lineages, namely the germline and soma. The germ-soma separation is one of the earliest events of embryonic development.
Hong YunHan +4 more
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To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm [PDF]
International Journal of Molecular Sciences, 2021 In the human embryo, the genetic program that orchestrates germ cell specification involves the activation of epigenetic and transcriptional mechanisms that make the germline a unique cell population continuously poised between germness and pluripotency. Germ cell tumors, neoplasias originating from fetal or neonatal germ cells, maintain such dichotomy
Massimo De Felici +5 more
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Frontiers in Cell and Developmental Biology, 2018 Germ cell research in vertebrates has traditionally been challenging, but recent breakthroughs have overcome technical difficulties, demonstrating and expanding the power of the zebrafish experimental system for their analysis in vivo. Exploiting the transparency of the zebrafish embryo, germ cell migration was the first topic that moved the germ cells
Roland Dosch, Roland Dosch
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Germ cell determination and the developmental origin of germ cell tumors [PDF]
Development, 2021 ABSTRACT In each generation, the germline is tasked with producing somatic lineages that form the body, and segregating a population of cells for gametogenesis. During animal development, when do cells of the germline irreversibly commit to producing gametes?
Peter K. Nicholls, David C. Page
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Stem cells of Hydra magnipapillata can differentiate into somatic cells and germ line cells [PDF]
, 1987 We investigated whether all stem cells of Hydra can differentiate both somatic cells and gametes or if a separate germ line exists in these phylogenetically old organisms.
Bosch, Thomas C. G., David, Charles N.
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Current Opinion in Genetics & Development, 1999 Recently, cell signaling has been shown to be required for the formation of germ cells in the mouse embryo, direct observation of germ cell migration in living mouse embryos has been achieved, novel genes that control germ-cell migration have been identified in Drosophila, and the roles of many components of germ plasm in several species have become ...
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Cell, 2008 Germ cells are the only cell type capable of generating an entirely new organism. In order to execute germline-specific functions and to retain the capacity for totipotency, germ cells repress somatic differentiation, interact with a specialized microenvironment, and use germline-specific networks of RNA regulation.
Cinalli, Ryan M. +2 more
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Protein interactions in Xenopus germ plasm RNP particles [PDF]
, 2013 Hermes is an RNA-binding protein that we have previously reported to be found in the ribonucleoprotein (RNP) particles of Xenopus germ plasm, where it is associated with various RNAs, including that encoding the germ line determinant Nanos1.
Nijjar, Sarbjit +6 more
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Ontological Differences in First Compared to Third Trimester Human Fetal Placental Chorionic Stem Cells [PDF]
, 2012 Human mesenchymal stromal/stem cells (MSC) isolated from fetal tissues hold promise for use in tissue engineering applications and cell-based therapies, but their collection is restricted ethically and technically.
Vanleene, Maximilien +55 more
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, 2012 The germline of Caenorhabditis elegans derives from a single founder cell, the germline blastomere P(4). P(4) is the product of four asymmetric cleavages that divide the zygote into distinct somatic and germline (P) lineages. P(4) inherits a specialized cytoplasm ("germ plasm") containing maternally encoded proteins and RNAs.
Jennifer T, Wang, Geraldine, Seydoux
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