Results 31 to 40 of about 226,104 (262)

CPEB3 Maintains Developmental Competence of the Oocyte

Cells
Mammalian oocyte development depends on the temporally controlled translation of maternal transcripts, particularly in the coordination of meiotic and early embryonic development when transcription has ceased.
Lucie Lamacova, Denisa Jansova, Zongliang Jiang, Michal Dvoran, Daria Aleshkina, Rajan Iyyappan, Anna Jindrova, Heng-Yu Fan, Yuxuan Jiao, Andrej Susor   +9 more
doaj   +1 more source

Autophagy and apoptosis act as partners to induce germ cell death after heat stress in mice. [PDF]

PLoS ONE, 2012
Testicular heating suppresses spermatogenesis which is marked by germ cell loss via apoptotic pathways. Recently, it is reported that autophagy also can be induced by heat treatment in somatic cells.
Mianqiu Zhang, Min Jiang, Ye Bi, Hui Zhu, Zuomin Zhou, Jiahao Sha   +5 more
doaj   +1 more source

Sex Specification and Heterogeneity of Primordial Germ Cells in Mice.

PLoS ONE, 2015
In mice, primordial germ cells migrate into the genital ridges by embryonic day 13.5 (E13.5), where they are then subjected to a sex-specific fate with female and male primordial germ cells undergoing mitotic arrest and meiosis, respectively.
Akihiko Sakashita, Yukiko Kawabata, Yuko Jincho, Shiun Tajima, Soichiro Kumamoto, Hisato Kobayashi, Yasuhisa Matsui, Tomohiro Kono   +7 more
doaj   +1 more source

WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. [PDF]

PLoS ONE, 2010
Female germ cells are essential for organogenesis of the ovary; without them, ovarian follicles do not form and functional and structural characteristics of the ovary are lost.
Chia-Feng Liu, Keith Parker, Humphrey H-C Yao   +2 more
doaj   +1 more source

RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary.

PLoS ONE, 2011
Differentiation of germ cells into male gonocytes or female oocytes is a central event in sexual reproduction. Proliferation and differentiation of fetal germ cells depend on the sex of the embryo.
Anne-Amandine Chassot, Elodie P Gregoire, Rowena Lavery, Makoto M Taketo, Dirk G de Rooij, Ian R Adams, Marie-Christine Chaboissier   +6 more
doaj   +1 more source

Germ cell chromatin

Biology of Reproduction
Abstract During mammalian gametogenesis, the chromatin landscape is especially dynamic. Primordial germ cells (PGCs), the precursors to mature male and female gametes, are a transient and small cell population that undergoes profound epigenetic reprogramming. Our knowledge of this process has come primarily from descriptive studies of
Stylianos Bakoulis, Kathleen R Stewart-Morgan   +1 more
openaire   +3 more sources

Optimization of In Vitro Culture Conditions of Sturgeon Germ Cells for Purpose of Surrogate Production

Animals, 2019
To expand germ cell populations and provide a consistent supply for transplantation, we established basal culture conditions for sturgeon germ cells and subsequently increased their mitotic activity by eliminating gonad somatic cells, supplementing with ...
Xuan Xie, Ping Li, Martin Pšenička, Huan Ye, Christoph Steinbach, Chuangju Li, Qiwei Wei   +6 more
doaj   +1 more source

The genome and the germ cell.

Genome biology, 2003
A report on the third biennial Cold Spring Harbor Laboratory meeting on Germ Cells, Cold Spring Harbor, USA, 9-13 October 2002.
Molyneaux, Kathleen, Wylie, Christopher
openaire   +2 more sources

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla, Sean Carter, Andrew Wood, Sandra Staffieri, Andrew Dodgshun, David D. Eisenstat, Michael Sullivan   +6 more
wiley   +1 more source

Absence of CDK12 in oocyte leads to female infertility

Cell Death and Disease
Transcriptional activity and gene expression are critical for the development of mature, meiotically competent oocytes. Our study demonstrates that the absence of cyclin-dependent kinase 12 (CDK12) in oocytes leads to complete female sterility, as fully ...
Denisa Jansova, Veronika Sedmikova, Fatima J. Berro, Daria Aleshkina, Michal Dvoran, Michal Kubelka, Jitka Rezacova, Jana Rutarova, Jiri Kohoutek, Andrej Susor   +9 more
doaj   +1 more source