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Primordial Germ Cells: Current Knowledge and Perspectives [PDF]
Stem Cells International, 2016 Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is ...
Aleksandar Nikolic +4 more
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Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors
Cell Reports, 2019 Summary: In vitro gametogenesis is the process of making germline cells from human pluripotent stem cells. The foundation of this model is the quality of the first progenitors called primordial germ cells (PGCs), which in vivo are specified during the ...
Di Chen +11 more
doaj +2 more sources
Primordial Germ Cell Specification and Migration [version 1; referees: 3 approved] [PDF]
F1000Research, 2015 Primordial germ cells are the progenitor cells that give rise to the gametes. In some animals, the germline is induced by zygotic transcription factors, whereas in others, primordial germ cell specification occurs via inheritance of maternally provided ...
Florence Marlow
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Mammalian primordial germ cell specification [PDF]
Development, 2021 The peri-implantation window of mammalian development is the crucial window for primordial germ cell (PGC) specification. Whereas pre-implantation dynamics are relatively conserved between species, the implantation window marks a stage of developmental ...
Grace V. Hancock +3 more
semanticscholar +3 more sources
Nature Communications, 2018 Human embryonic stem cells can be differentiated in vitro into primordial germ cell-like cells (PGCLCs) that resemble early primordial germ cells (PGCs). Here the authors transplant PGCLCs generated from rhesus macaque iPSCs into mouse and rhesus macaque
Enrique Sosa +13 more
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Sex Specification and Heterogeneity of Primordial Germ Cells in Mice.
PLoS ONE, 2015 In mice, primordial germ cells migrate into the genital ridges by embryonic day 13.5 (E13.5), where they are then subjected to a sex-specific fate with female and male primordial germ cells undergoing mitotic arrest and meiosis, respectively.
Akihiko Sakashita +7 more
doaj +2 more sources
Analysis of chicken primordial germ cells [PDF]
Cytotechnology, 2008 Primordial germ cells (PGCs) are precursors of germline cells. Although avian PGCs have been used to produce transgenic birds, their characteristics largely remain unknown. In this study, we isolated PGCs from chicken embryos at various developmental stages and analyzed the gene expression.
Ken-Ichi Nishijima +2 more
exaly +3 more sources
Enhanced cultivation of chicken primordial germ cells [PDF]
Scientific Reports, 2023 The cultivation and expansion of chicken primordial germ cells (cPGCs) are of critical importance for both biotechnological applications and the management of poultry genetic biodiversity.
Nima Dehdilani +8 more
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In vitro differentiation of germ cells from stem cells: a comparison between primordial germ cells and in vitro derived primordial germ cell-like cells [PDF]
Cell Death & Disease, 2015 Stem cells are unique cell types capable to proliferate, some of them indefinitely, while maintaining the ability to differentiate into a few or any cell lineages. In 2003, a group headed by Hans R.
Wei Ge +3 more
semanticscholar +4 more sources
Complete in vitro generation of fertile oocytes from mouse primordial germ cells
Proceedings of the National Academy of Sciences of the United States of America, 2016 Ren Tanimoto +2 more
exaly +2 more sources