Results 21 to 30 of about 137,442 (242)

Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice. [PDF]

PLoS ONE, 2013
Maintenance and maturation of primordial germ cells is controlled by complex genetic and epigenetic cascades, and disturbances in this network lead to either infertility or malignant aberration.
Jana Schemmer, Marcos J Araúzo-Bravo, Natalie Haas, Sabine Schäfer, Susanne N Weber, Astrid Becker, Dawid Eckert, Andreas Zimmer, Daniel Nettersheim, Hubert Schorle   +9 more
doaj   +1 more source

Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation

Nature Cell Biology, 2020
X-chromosome dosage compensation in female placental mammals is achieved by X-chromosome inactivation (XCI). Human pre-implantation embryos are an exception, in which dosage compensation occurs by X-chromosome dampening (XCD).
Tsotne Chitiashvili, I. Dror, Rachel Kim, Fei-Man Hsu, R. Chaudhari, Erica C. Pandolfi, Di Chen, Simone Liebscher, K. Schenke-Layland, K. Plath, A. Clark   +10 more
semanticscholar   +1 more source

Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification.

Cell Stem Cell, 2020
Dynamic pluripotent stem cell (PSC) states are in vitro adaptations of pluripotency continuum in vivo. Previous studies have generated a number of PSCs with distinct properties.
Leqian Yu, Yulei Wei, Haixi Sun, A. K. Mahdi, Carlos A. Pinzon Arteaga, M. Sakurai, Daniel A. Schmitz, Canbin Zheng, Emily D. Ballard, Jie Li, N. Tanaka, Aoi Kohara, Daiji Okamura, A. Mutto, Ying Gu, P. Ross, Jun Wu   +16 more
semanticscholar   +1 more source

PAR6, a potential marker for the germ cells selected to form primordial follicles in mouse ovary. [PDF]

PLoS ONE, 2009
Partitioning-defective proteins (PAR) are detected to express mainly in the cytoplast, and play an important role in cell polarity. However, we showed here that PAR6, one kind of PAR protein, was localized in the nuclei of mouse oocytes that formed ...
Jing Wen, Hua Zhang, Ge Li, Guanping Mao, Xiufen Chen, Jianwei Wang, Meng Guo, Xinyi Mu, Hong Ouyang, Meijia Zhang, Guoliang Xia   +10 more
doaj   +1 more source

An Extended Culture System that Supports Human Primordial Germ Cell-like Cell Survival and Initiation of DNA Methylation Erasure

Stem Cell Reports, 2020
Summary: The development of an in vitro system in which human primordial germ cell-like cells (hPGCLCs) are generated from human pluripotent stem cells (hPSCs) has been invaluable to further our understanding of human primordial germ cell (hPGC ...
Joanna J. Gell, Wanlu Liu, Enrique Sosa, Alex Chialastri, Grace Hancock, Yu Tao, Sissy E. Wamaitha, Grace Bower, Siddharth S. Dey, Amander T. Clark   +9 more
doaj   +1 more source

Generation of NANOS3-mCherry reporter human embryonic stem cell line SYSUe-009-A using CRISPR/Cas9

Stem Cell Research, 2023
NANOS3 is a zinc-finger containing RNA-binding protein that has been demonstrated to be highly expressed in human primordial germ cell(hPGC), thus NANOS3 can serve as a marker for hPGC development.
Ruirui Guo, Simin Yuan, Bing Li, Jichang Wang, Chuanbo Sun   +4 more
doaj   +1 more source

Effect of Mytomycin C Treatment on Feeder Cells and the Proliferation of Cultured Chicken Primordial Germ Cells Isolated from Embryonic Blood

The Journal of Poultry Science, 2001
Chicken primordial germ cells isolated from embryonic blood were cultured in vitro on feeder cells derived from the gonads of 7-day incubated embryos. Primordial germ cells were proliferated about 13 times during the 4 day culture period on the feeder ...
Mitsuru Naito, Akiko Sano, Takahiro Tagami, Takashi Harumi, Yuko Matsubara, Takashi Kuwana   +5 more
doaj   +1 more source

Abundance of Early Embryonic Primordial Germ Cells Promotes Zebrafish Female Differentiation as Revealed by Lifetime Labeling of Germline

Marine Biotechnology, 2019
Teleost sex differentiation largely depends on the number of undifferentiated germ cells. Here, we describe the generation and characterization of a novel transgenic zebrafish line, Tg(piwil1:egfp-UTRnanos3)ihb327Tg, which specifically labels the whole ...
Ding Ye, Lin Zhu, Qifeng Zhang, Feng Xiong, Houpeng Wang, Xiaosi Wang, Mudan He, Zuoyan Zhu, Yonghua Sun   +8 more
semanticscholar   +1 more source

IDENTIFICATION OF PRIMORDIAL GERM CELLS IN EARLY PHEASANT (PHASIANUS COLCHICUS) EMBRYO [PDF]

Exploratory Animal and Medical Research
The aim of this study is identification of primordial germ cells during their circulation in the blood stream and migration to the primary gonads in pheasant embryo. The blood was taken from stages 14-17 and genital ridge tissue was taken from stages 20-
Entekhab Hameed Abed Al-Shuwaili, Azam Hosseini, Abolghasem Nabipour   +2 more
doaj   +1 more source

Sexual Differentiation and Primordial Germ Cell Distribution in the Early Horse Fetus

Animals, 2021
It was the aim of this study to characterize the development of the gonads and genital ducts in the equine fetus around the time of sexual differentiation. This included the identification and localization of the primordial germ cell population.
Dragos Scarlet, Stephan Handschuh, Ursula Reichart, Giorgia Podico, Robyn E. Ellerbrock, Sebastián Demyda-Peyrás, Igor F. Canisso, Ingrid Walter, Christine Aurich   +8 more
doaj   +1 more source