Results 41 to 50 of about 137,442 (242)
A PAX5-OCT4-PRDM1 Developmental Switch Specifies Human Primordial Germ Cells
Nature Cell Biology, 2018 Dysregulation of genetic pathways during human germ cell development leads to infertility. Here, we analysed bona fide human primordial germ cells (hPGCs) to probe the developmental genetics of human germ cell specification and differentiation.
Fang Fang +13 more
semanticscholar +1 more source
Formation, Application, and Significance of Chicken Primordial Germ Cells: A Review
Animals, 2023 Chicken is one of the most widely consumed sources of protein globally. Primordial germ cells (PGCs) are the precursors for ova and sperm. One of the early embryogenesis events in most animals is the segregation of the somatic and germ lineages.
Mathan +6 more
doaj +1 more source
In vitro culture and characterization of duck primordial germ cells
Poultry Science, 2018 This study aimed to isolate, culture, and characterize duck primordial germ cells (PGCs) and to compare these cells with chicken PGCs. We first cultured Muscovy duck (Cairina moschata) circulating PGCs and gonadal PGCs (gPGCs) in the modified serum ...
Yi-Chen Chen +8 more
semanticscholar +1 more source
The Neonatal and Adult Human Testis Defined at the Single-Cell Level
Cell Reports, 2019 Summary: Spermatogenesis has been intensely studied in rodents but remains poorly understood in humans. Here, we used single-cell RNA sequencing to analyze human testes.
Abhishek Sohni +10 more
doaj +1 more source
Production of live fish derived from frozen germ cells via germ cell transplantation
Stem Cell Research, 2018 The conservation of endangered fish is an urgent issue. Although cryo-banking of fish gametes might ultimately help conserve endangered fish, cryopreservation of fish eggs or embryos is still not possible due to their large size and high yolk content ...
Goro Yoshizaki, Seungki Lee
doaj +1 more source
Induction of pluripotency in primordial germ cells.
Histology and histopathology, 2011 Primordial germ cells (PGCs) are the founder cells of all gametes. PGCs differentiate from pluripotent epiblasts cells by mesodermal induction signals during gastrulation. Although PGCs are unipotent cells that eventually differentiate into only sperm or oocytes, they dedifferentitate to pluripotent stem cells known as embryonic germ cells (EGCs) in ...
Kimura, Tohru, Nakano, Toru
openaire +3 more sources
A role for Lin28 in primordial germ-cell development and germ-cell malignancy [PDF]
Nature, 2009 The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwart efforts to investigate molecular mechanisms of germ-cell specification. stella (also called Dppa3) marks the rare founder population of the germ lineage.
West, Jason A. +11 more
openaire +2 more sources
Single-cell transcriptome landscape of ovarian cells during primordial follicle assembly in mice.
PLoS Biology, 2020 Primordial follicle assembly in the mouse occurs during perinatal ages and largely determines the ovarian reserve that will be available to support the reproductive life span.
Jun-Jie Wang +10 more
doaj +1 more source
Scientific Reports, 2017 The ongoing progress in primordial germ cell derivation and cultivation is opening new ways in reproductive biotechnology. This study tested whether functional sperm cells can be matured from genetically manipulated primordial germ cells after ...
P. Trefil +10 more
semanticscholar +1 more source
Heterogeneity of primordial germ cells
, 2019 Primordial germ cells (PGCs) must complete a complex and dynamic developmental program during embryogenesis to establish the germline. This process is highly conserved and involves a diverse array of tasks required of PGCs, including migration, survival, sex differentiation, and extensive epigenetic reprogramming.
Nguyen, Daniel H +2 more
openaire +5 more sources