Results 61 to 70 of about 137,442 (242)

Collectively stabilizing and orienting posterior migratory forces disperses cell clusters in vivo

Nature Communications, 2020
During development, primordial germ cell clusters undergo dispersal but how cell–cell adhesion and contractility are coordinated during this process in vivo is unclear. Here, the authors show that Drosophila primordial germ cells utilize migratory forces
B. Lin, J. Luo, R. Lehmann
doaj   +1 more source

Stage-specific demethylation in primordial germ cells safeguards against precocious differentiation

Developmental Cell, 2016
Summary Remodeling DNA methylation in mammalian genomes can be global as seen in pre-implantation embryos and primordial germ cells (PGCs), or locus-specific, which can regulate neighboring gene expression.
Joseph Hargan-Calvopiña, Sara K Taylor, H. Cook, Zhongxun Hu, Serena A. Lee, M. Yen, Yih-Shien Chiang, Pao-Yang Chen, A. Clark   +8 more
semanticscholar   +1 more source

Gonadal development in scorpion mud‐turtles, Kinosternon scorpioides, in a controlled environment

The Anatomical Record, EarlyView.
Stage 20 was identified as the critical point for gonadal differentiation in Kinosternon scorpioides, providing key insights into sex determination. These findings enhance conservation strategies by supporting reproductive management and population viability in both in situ and ex situ programs. Abstract Research on gonadal development including sexual
Brenda Braga, Verônica Oliveira‐Bahia, Maria Auxiliadora Ferreira, José Ribamar Felipe Marques, Diva Araújo Guimarães   +4 more
wiley   +1 more source

RNA-binding proteins in human oogenesis: Balancing differentiation and self-renewal in the female fetal germline

Stem Cell Research, 2017
Primordial germ cells undergo three significant processes on their path to becoming primary oocytes: the initiation of meiosis, the formation and breakdown of germ cell nests, and the assembly of single oocytes into primordial follicles.
Roseanne Rosario, Andrew J. Childs, Richard A. Anderson   +2 more
doaj   +1 more source

Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ Cells

PLoS ONE, 2016
The CRISPR/Cas9 system has been applied in a large number of animal and plant species for genome editing. In chickens, CRISPR has been used to knockout genes in somatic tissues, but no CRISPR-mediated germline modification has yet been reported.
Lazar Dimitrov, Darlene Pedersen, Kathryn H Ching, H. Yi, E. Collarini, S. Izquierdo, Marie-Cecile van de Lavoir, P. Leighton   +7 more
semanticscholar   +1 more source

Guidance of primordial germ cell migration [PDF]

Current Opinion in Cell Biology, 2004
Primordial germ cells (PGCs), the progenitors of the gametes, migrate from the position where they are specified towards the region where the gonad develops. To reach their target, the PGCs obtain directional cues from cells positioned along their migration path.
openaire   +4 more sources

Unraveling ovarian histology: The key morphological aspects that spur the development of the Fossa ovarii in equine

The Anatomical Record, EarlyView.
Abstract The equine ovary exhibits unique structural and developmental features that distinguish it from those of other domestic species, including the presence of an ovulation fossa and an inversion of cortical and medullary layers. This study aimed to investigate the morphostructural development of the equine fetal ovary, with particular emphasis on ...
Laura Ver Goltz, Silvio Pires Gomes, Bruno Cesar Schimming, Fabio Cesar Magioli Abdala, Maria Angélica Miglino, Tais Harumi de Castro Sasahara   +5 more
wiley   +1 more source

Insights into female germ cell biology: from in vivo development to in vitro derivations

Asian Journal of Andrology, 2015
Understanding the mechanisms of human germ cell biology is important for developing infertility treatments. However, little is known about the mechanisms that regulate human gametogenesis due to the difficulties in collecting samples, especially germ ...
Dajung Jung, Kehkooi Kee
doaj   +1 more source

Aged mice ovaries harbor stem cells and germ cell nests but fail to form follicles

Journal of Ovarian Research, 2022
Background We recently published evidence to suggest that two populations of stem cells including very small embryonic-like stem cells (VSELs) and ovarian stem cells (OSCs) in ovary surface epithelium (OSE) undergo proliferation/differentiation, germ ...
Diksha Sharma, Deepa Bhartiya
doaj   +1 more source

Determining the timeline of gonadal and genital differentiation in male and female equine fetuses allows for early detection and intervention in malformations

The Anatomical Record, EarlyView.
Abstract Sexual differentiation in the equine fetus involves coordinated morphogenetic processes that shape both the gonads and the genital ducts. Although the formation of testes and ovaries has been relatively well documented, the temporal dynamics and morphometric patterns of the mesonephric (Wolffian) and paramesonephric (Müllerian) ducts remain ...
Tais Harumi de Castro Sasahara, Silvio Pires Gomes, Fabio Cesar Magioli Abdala, Bruno Cesar Schimming, Maria Angelica Miglino   +4 more
wiley   +1 more source