Results 51 to 60 of about 137,442 (242)

Reprogramming primordial germ cells into pluripotent stem cells.

PLoS ONE, 2008
BackgroundSpecification of primordial germ cells (PGCs) results in the conversion of pluripotent epiblast cells into monopotent germ cell lineage. Blimp1/Prmt5 complex plays a critical role in the specification and maintenance of the early germ cell ...
Gabriela Durcova-Hills, Fuchou Tang, Gina Doody, Reuben Tooze, M Azim Surani   +4 more
doaj   +1 more source

The dynamic expression of SOX17 in germ cells from human female foetus and adult ovaries after specification

Frontiers in Endocrinology, 2023
BackgroundSOX17 has been identified as a critical factor in specification of human primordial germ cells, but whether SOX17 regulates development of germ cells after sex differentiation is poorly understood. MethodsWe collected specimens of gonadal ridge
Ying-Yi Luo, Ying-Yi Luo, Hui-Ying Jie, Ke-Jun Huang, Ke-Jun Huang, Bing Cai, Xiu Zhou, Ming-Yi Liang, Can-Quan Zhou, Qing-Yun Mai   +9 more
doaj   +1 more source

Transcriptional quiescence in primordial germ cells

Critical Reviews in Biochemistry and Molecular Biology, 2018
In most animal species, newly formed primordial germ cells (PGCs) acquire the special characteristics that distinguish them from the surrounding somatic cells. Proper fate specification of the PGCs is coupled with transcriptional quiescence, whether they are segregated by determinative or inductive mechanisms. Inappropriate differentiation of PGCs into
Lyubov A. Lebedeva, Konstantin V. Yakovlev, Eugene N. Kozlov, Paul Schedl, Girish Deshpande, Yulii V. Shidlovskii   +5 more
openaire   +3 more sources

Review of Differentiation and Proliferation of Primordial Germ Cells in Culture [PDF]

Journal of Fasa University of Medical Sciences, 2011
Primordial germ cells (PGCs) are highly specialized cell population that arises from the epiblast in vivo. There are three critical steps in the life cycle of these cells: 1-Specification 2-migration and proliferation 3-prenatal and postnatal sex ...
Zohreh Makoolati, Majid Naghdi
doaj   +1 more source

Biology of teleost primordial germ cells (PGCs) and spermatogonia: biotechnological applications.

, 2017
This review provides a general view on teleost germline development using primordial germ cells (PGCs) or spermatogonia (SG), highlighting recent progress in research on these two cell types in teleost fishes.
V. Robles, M. F. Riesco, M. Pšenička, Taiju Saito, D. G. Valcarce, E. Cabrita, P. Herráez   +6 more
semanticscholar   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Tracing the transitions from pluripotency to germ cell fate with CRISPR screening

Nature Communications, 2018
Primordial Germ Cell-Like Cells (PGCLCs) are an in vitro model for primordial germ cell development. Here, the authors couple a novel compound reporter with CRISPR screening to identify key genes for exit from pluripotency and acquisition of PGCLC fate ...
Jamie A. Hackett, Yun Huang, Ufuk Günesdogan, Kristjan A. Gretarsson, Toshihiro Kobayashi, M. Azim Surani   +5 more
doaj   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Germ Cell Derivation from Pluripotent Stem Cells for Understanding In Vitro Gametogenesis

Cells, 2021
Assisted reproductive technologies (ARTs) have developed considerably in recent years; however, they cannot rectify germ cell aplasia, such as non-obstructive azoospermia (NOA) and oocyte maturation failure syndrome. In vitro gametogenesis is a promising
Tae-Kyung Hong, Jae-Hoon Song, So-Been Lee, Jeong-Tae Do   +3 more
doaj   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source