Results 311 to 320 of about 462,838 (340)
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2006
Primordial germ cells, which carry the responsibility for perpetuation of the species, are set aside from their somatic neighbors very early in mammalian embryonic development. The founder population of germ cells is rare and difficult to identify and isolate in quantities suitable for molecular and biochemical analysis, thereby highlighting the ...
George Q. Daley, Niels Geijsen
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Primordial germ cells, which carry the responsibility for perpetuation of the species, are set aside from their somatic neighbors very early in mammalian embryonic development. The founder population of germ cells is rare and difficult to identify and isolate in quantities suitable for molecular and biochemical analysis, thereby highlighting the ...
George Q. Daley, Niels Geijsen
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Annals of Internal Medicine, 1981
Excerpt To the editor: The letters by Page (1) and Newcomer (2) in the May issue and the comments by other physicians in response to our article on unrecognized germ cell cancers (3) warrant a repl...
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Excerpt To the editor: The letters by Page (1) and Newcomer (2) in the May issue and the comments by other physicians in response to our article on unrecognized germ cell cancers (3) warrant a repl...
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New England Journal of Medicine, 2007
Testicular cancer is rare, accounting for 1% to 2% of all male malignancies. Nearly 90% to 95% of tumors arising in testis are germ cell in origin. Other sites of malignant germ cell tumors include the retroperitoneum, mediastinum, sacrococcygeal region, and pineal gland. The highest incidence is seen in Scandinavian countries, particularly Denmark (1).
De Giorgi U, Pedrazzoli P, Rosti G
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Testicular cancer is rare, accounting for 1% to 2% of all male malignancies. Nearly 90% to 95% of tumors arising in testis are germ cell in origin. Other sites of malignant germ cell tumors include the retroperitoneum, mediastinum, sacrococcygeal region, and pineal gland. The highest incidence is seen in Scandinavian countries, particularly Denmark (1).
De Giorgi U, Pedrazzoli P, Rosti G
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Seminars in Reproductive Medicine, 2005
Transplantation of male germ line stem cells from a fertile donor to the testis of an infertile recipient restores donor-derived spermatogenesis in the recipient testis. The resulting sperm pass the donor genotype to the offspring of the recipient. Germ cell transplantation helped to elucidate the biology of male germ line stem cells and their niche in
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Transplantation of male germ line stem cells from a fertile donor to the testis of an infertile recipient restores donor-derived spermatogenesis in the recipient testis. The resulting sperm pass the donor genotype to the offspring of the recipient. Germ cell transplantation helped to elucidate the biology of male germ line stem cells and their niche in
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2019
Germ cells undergo epigenome reprogramming for proper development of the next generation. The achievement of in vitro germ cell derivation from human and mouse pluripotent stem cells and further differentiation in a plane culture and in aggregation with gonadal somatic cells offers unprecedented opportunities for investigation of the germ cell ...
Mitinori Saitou, Kazuki Kurimoto
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Germ cells undergo epigenome reprogramming for proper development of the next generation. The achievement of in vitro germ cell derivation from human and mouse pluripotent stem cells and further differentiation in a plane culture and in aggregation with gonadal somatic cells offers unprecedented opportunities for investigation of the germ cell ...
Mitinori Saitou, Kazuki Kurimoto
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Science, 2017 Plant Biology Unlike animals, plants do not set aside a germline. Instead, germ cells are developed on demand from somatic lineages. Zhao et al. examined the regulatory pathways that manage the transition from somatic to germ cell development in the small plant Arabidopsis (see the Perspective by Vielle-Calzada).
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Current Opinion in Oncology, 2005
Germ cell tumors most frequently develop from embryonal germ cells and may have tumor constituents representing ectodermal, mesodermal, and endodermal lineages.
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Germ cell tumors most frequently develop from embryonal germ cells and may have tumor constituents representing ectodermal, mesodermal, and endodermal lineages.
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Embryonic Germ Cells: When Germ Cells Become Stem Cells
Seminars in Reproductive Medicine, 2006Embryonic germ cells (EGCs) are pluripotent stem cells derived from primordial germ cells (PGCs). PGCs are progenitors of adult gametes, which diverge from the somatic lineage between late embryonic to early fetal development. First derived in the mouse, EGCs have also been derived from human, chicken, and pig.
John D. Gearhart +3 more
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Current Opinion in Oncology, 1999
The publication of the proceedings of Fourth Workshop on Carcinoma in situ was an impressive leap in our understanding of the interaction between prenatal and postpubertal factors in the development of germ cell cancer as well as increased insight into the molecular events that are involved in the development of these tumors. From this work, physicians
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The publication of the proceedings of Fourth Workshop on Carcinoma in situ was an impressive leap in our understanding of the interaction between prenatal and postpubertal factors in the development of germ cell cancer as well as increased insight into the molecular events that are involved in the development of these tumors. From this work, physicians
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Developmental arrest of germ cells in the pathogenesis of germ cell neoplasia
APMIS, 1998Clinical observations and epidemiological evidence suggest that important aetiopathological events that cause neoplastic transformation of the male germ cell may occur in fetal life or early infancy. The incidence of germ cell neoplasia is high in individuals with various disorders of gonadal development and sexual differentiation, such as gonadal ...
Niels Jørgensen +4 more
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