Results 71 to 80 of about 11,144,846 (357)

Cyp26b1 expression in murine Sertoli cells is required to maintain male germ cells in an undifferentiated state during embryogenesis. [PDF]

PLoS ONE, 2009
In mammals, germ cells within the developing gonad follow a sexually dimorphic pathway. Germ cells in the murine ovary enter meiotic prophase during embryogenesis, whereas germ cells in the embryonic testis arrest in G0 of mitotic cell cycle and do not ...
Hui Li, Glenn MacLean, Don Cameron, Margaret Clagett-Dame, Martin Petkovich   +4 more
doaj   +1 more source

Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis. [PDF]

, 2019
Mitochondria are essential organelles that have recently emerged as hubs for several metabolic and signaling pathways in the cell. Mitochondrial morphology is regulated by constant fusion and fission events to maintain a functional mitochondrial network ...
Jones, D Leanne, Sênos Demarco, Rafael
core   +1 more source

Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors [PDF]

, 2016
Type II germ cell tumors arise after puberty from a germ cell that was incorrectly programmed during fetal life. Failure of testicular germ cells to properly differentiate can lead to the formation of germ cell neoplasia in situ of the testis; this ...
Bowles, J. (Josephine), Burnet, G. (Guillaume), Gillis, A.J.M. (Ad), Koopman, P. (Peter), Looijenga, L.H.J. (Leendert), Spiller, C.M. (Cassy M.), Stoop, J.A. (Hans)   +6 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

The fate of germ cells in cryptorchid testis

Frontiers in Endocrinology
Cryptorchidism in males constitutes a notable risk factor for both infertility and testicular cancer. Infertility in adulthood is closely linked to the germ cell status in childhood.
Jorgen Thorup, Jorgen Thorup, Simone Hildorf, Andrea E. Hildorf, Jonas M. Baastrup, Linn Salto Mamsen, Claus Yding Andersen, Tina E. Olsen, Dina Cortes, Dina Cortes   +9 more
doaj   +1 more source

The single cell transcriptional landscape of mammalian organogenesis

Nature, 2019
Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of the three germ layers transform into an embryo that includes most of the major internal and external organs. Here we investigate the transcriptional dynamics of mouse
Junyue Cao, M. Spielmann, Xiaojie Qiu, Xingfan Huang, Daniel M. Ibrahim, Andrew J. Hill, Fan Zhang, S. Mundlos, Lena Christiansen, F. Steemers, C. Trapnell, J. Shendure   +11 more
semanticscholar   +1 more source

Workshop on Germ Cells [PDF]

Frontiers in Cell and Developmental Biology, 2018
Germ cell research in vertebrates has traditionally been challenging, but recent breakthroughs have overcome technical difficulties, demonstrating and expanding the power of the zebrafish experimental system for their analysis in vivo. Exploiting the transparency of the zebrafish embryo, germ cell migration was the first topic that moved the germ cells
Roland Dosch, Roland Dosch
openaire   +4 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Actomyosin-mediated apical constriction promotes physiological germ cell death in C. elegans.

PLoS Biology
Germ cell apoptosis in Caenorhabditis elegans hermaphrodites is a physiological process eliminating around 60% of all cells in meiotic prophase to maintain tissue homeostasis. In contrast to programmed cell death in the C.
Tea Kohlbrenner, Simon Berger, Ana Cristina Laranjeira, Tinri Aegerter-Wilmsen, Laura Filomena Comi, Andrew deMello, Alex Hajnal   +6 more
doaj   +1 more source

Regulation of the G2/M Transition in Rodent Oocytes [PDF]

, 2010
Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling ...
Downs, Stephen
core   +2 more sources