Results 121 to 130 of about 11,236 (211)

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Christian G. Bustillos, Esther M. Peluso, Sophia L. Cha, Melissa G. Lechner, Maureen A. Su   +4 more
wiley   +1 more source

CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility [PDF]

, 2017
The role of genetic polymorphisms in pediatric brain tumor (PBT) etiology is poorly understood. In this study, we tested the hypothesis that single nucleotide polymorphisms identified by genome-wide association studies on adult glioma are also associated
Adel Fahmideh, Maral, Feychting, Maria, Grotzer, Michael A., Johansen, Christoffer, Kuehni, Claudia E., Lannering, Birgitta, Lavebratt, Catharina, Prochazka, Michaela, Röösli, Martin, Schmidt, Lisbeth S., Schüz, Joachim, Tynes, Tore   +11 more
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The X Factor in Immunity: Sex Differences Shaped by the X Chromosome

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera   +2 more
wiley   +1 more source

Analysis of histological frequency and pediatric cancer in Rondônia, Western Amazonia (Brazil) [PDF]

, 2018
Objective:Describe the histological and cancer frequency in children and adolescents attended at the Hospital de Base Dr. Ary Pinheiro and the Hospital de Barretos / Rondônia, Western Amazonia, in the years 2014 and 2015.
Aguiar, R. R. (Rodrigo), Almeida, F. M. (Fabrício), Paraguassú-Chaves, C. A. (Carlos), Romanholo, R. A. (Rafael), Souza, L. P. (Laurindo)   +4 more
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Clinical Correlates of Anxiety and Depression After Diagnosis of a Pediatric Brain Tumor

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Background The prevalence and clinical correlates of symptoms of anxiety and depression in pediatric patients with brain tumors are not well described. We aimed to identify clinical characteristics that are correlated with elevated symptoms of anxiety and depression following initial diagnosis.
Bryony J. Lucas, Se‐Kang Kim, Joan Yu, Ana Sofia C. Ibarrola, Heather H. Stancel, Kavyaa Choudry, Mary Elizabeth Moody, Krystal K. Christopher, David R. Grosshans, Arnold C. Paulino, Guillermo Aldave, M. Fatih Okcu, Murali M. Chintagumpala, Austin L. Brown, Michael E. Scheurer, Kimberly P. Raghubar, Lisa S. Kahalley   +16 more
wiley   +1 more source

High‐throughput single‐cell DNA methylation and chromatin accessibility co‐profiling with SpliCOOL‐seq

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
SpliCOOL‐seq achieves high‐throughput single‐cell co‐profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL‐seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Qingmei Shen, Enze Deng, Ling Luo, Jingna Zhang, Qifeng Yang, Dan Su, Xiaoying Fan   +6 more
wiley   +1 more source

Second-line high-dose chemotherapy in patients with mediastinal and retroperitoneal primary non-seminomatous germ cell tumors: the EBMT experience [PDF]

, 2017
Background: Results of second-line chemotherapy in patients with extragonadal non-seminomatous germ cell tumor (NSGCT) appear inferior to results in testicular NSGCT. Patients with retroperitoneal NSGCT achieve a comparable long-term survival rate of 30%,
Ballardini, M., Bornhauser, M., De Giorgi, U., Demirer, T., Kozak, T., Papiani, G., Rosti, G., Siegert, W., Taverna, C., Wandt, H.   +9 more
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Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Their bioactive constituents act through antioxidant, anti‐inflammatory, and metabolic‐regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in vitro findings.
Nighat Raza, Alina Sadaf, Reeha Mushtaq, Mirza Abid Mehmood, Luqman Amrao, Fakhar Islam, Muhammad Afzaal, Mohd Asif Shah   +7 more
wiley   +1 more source

Mosaic Li Fraumeni Syndrome Not Identified in Germinal Tissue

Molecular Genetics &Genomic Medicine, Volume 14, Issue 2, February 2026.
In this study, we presented the first clinical case report of mosaic Li Fraumeni syndrome eluding germinal tissue. This case highlights the complexity of interpreting mosaic variants in TP53, and the difficulty in relaying cancer and reproductive risk information in the context of mosaic Li Fraumeni syndrome.
Rhianna M. Urban, Nisha Kanwar, Megan A. Holdren, Megan F. Hoenig, Laura M. Rust, Myra J. Wick, Matthew J. Ferber, Zhiyv Niu, Sounak Gupta, Wei Shen   +9 more
wiley   +1 more source

What is new in Genitourinary Pathology? Recent developments and highlights of the new 2016 World Health Organization classification of tumors of the urinary system and male genital organs [PDF]

, 2016
Daniel Abensur Athanazio, Kiril Trpkov
core   +1 more source