Results 91 to 100 of about 1,521,712 (329)

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

open access: yesHepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu   +11 more
wiley   +1 more source

A Rare Case of Intracranial Nongerminomatous Germ Cell Tumor in a 21-Year-Old Romanian Male

open access: yesCase Reports in Oncological Medicine, 2020
Extragonadal germ cell tumors are a rare entity that is more prevalent in infants and young children, with preference to midline structures.
Minesh Nandi   +6 more
doaj   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

open access: yesAdvanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song   +17 more
wiley   +1 more source

Giant malignant sacrococcygeal germ cell tumor in a newborn: A rare case report

open access: yesRadiology Case Reports, 2022
Malignant germ cell tumors constitute about 3%-4% of all neoplasms occurring before the age of 15. They arise in the ovaries, the testes, and in several other locations, including the lower back, the chest, the brain, and the abdomen.
Carmela Brillantino   +9 more
doaj  

Familial testicular germ cell tumors in two brothers

open access: yesIJU Case Reports, 2020
Introduction Two percent of testicular germ cell tumors occur in family clusters. Here, we report metachronous testicular germ cell tumors in two brothers.
Senji Hoshi   +12 more
doaj   +1 more source

Comprehensive genetic analysis of poorly differentiated gastric cancer in young females

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Although the involvement of female sex hormones in the development of poorly differentiated gastric cancer in young females is controversial, our detailed analysis using RNA‐seq suggested that the female sex hormone, β‐estradiol plays a role in the development of poorly differentiated gastric cancer in young females. Abstract Aim The reasons behind the
Nobuhiro Nakazawa   +9 more
wiley   +1 more source

Mycosis Fungoides, Sézary Syndrome, and Cutaneous B‐Cell Lymphomas: 2025 Update on Diagnosis, Risk‐Stratification, and Management

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov   +2 more
wiley   +1 more source

Dysgerminoma with Embryonal Carcinoma, a Rare Ovarian Malignant Mixed Germ Cell Tumor in a 13-Year-Old Girl: A Case Report [PDF]

open access: yesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān
Introduction: Pediatric patients rarely develop ovarian tumors, but mainly develop ovarian germ cell tumors. Malignant germ cell tumors are generally rare and dysgerminoma is the most frequent malignant ovarian neoplasm in young and adolescent girls.
Mahsa Akbari Oryani   +3 more
doaj   +1 more source

Serial monitoring of serum alpha-fetoprotein and chorionic gonadotropin in males with germ cell tumors [PDF]

open access: bronze, 1979
Donna K. Thompson, James E. Haddow
openalex   +1 more source

International Consensus Histopathological Criteria for Subtyping Idiopathic Multicentric Castleman Disease Based on Machine Learning Analysis

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder classified into three recognized clinical subtypes—idiopathic plasmacytic lymphadenopathy (IPL), TAFRO, and NOS. Although clinical criteria are available for subtyping, diagnostically challenging cases with overlapping histopathological features highlight ...
Midori Filiz Nishimura   +14 more
wiley   +1 more source

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