Results 11 to 20 of about 1,521,712 (329)

Immunotherapy in Testicular Germ Cell Tumors

Frontiers in Oncology, 2020
Testicular germ cell tumors (TGCTs) are malignancies with very high curative potential even in metastatic settings, mainly due to the introduction of cisplatin in the treatment of this disease.
Katarina Kalavska, Katarina Kalavska, Silvia Schmidtova, Silvia Schmidtova, Michal Chovanec, Michal Mego, Michal Mego   +6 more
doaj   +2 more sources

Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium

Journal of Clinical Oncology, 2021
PURPOSE The classification of the International Germ Cell Cancer Collaborative Group (IGCCCG) plays a pivotal role in the management of metastatic germ cell tumors but relies on data of patients treated between 1975 and 1990.
S. Gillessen, N. Sauvé, L. Collette, G. Daugaard, R. de Wit, C. Albany, A. Tryakin, K. Fizazi, O. Ståhl, J. Gietema, U. de Giorgi, F. Cafferty, A. Hansen, T. Tandstad, R. Huddart, A. Necchi, C. Sweeney, X. Garcia-Del-Muro, D. Heng, A. Lorch, M. Chovanec, E. Winquist, P. Grimison, D. Feldman, A. Terbuch, M. Hentrich, C. Bokemeyer, H. Negaard, C. Fankhauser, J. Shamash, D. Vaughn, C. Sternberg, A. Heidenreich, J. Beyer   +33 more
semanticscholar   +1 more source

Identification of 22 susceptibility loci associated with testicular germ cell tumors

Nature Communications, 2021
Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with and without TGCT, respectively, for a genome ...
J. Pluta, L. Pyle, K. Nead, R. Wilf, Mingyao Li, N. Mitra, B. Weathers, K. D’Andrea, K. Almstrup, L. Anson-Cartwright, J. Benítez, Christopher D. Brown, S. Chanock, Chu Chen, V. Cortessis, A. Ferlin, C. Foresta, M. Gamulin, J. Gietema, Chiara Grasso, M. Greene, T. Grotmol, R. Hamilton, T. B. Haugen, R. Hauser, M. Hildebrandt, Matthew E Johnson, R. Karlsson, L. Kiemeney, D. Lessel, R. Lothe, J. Loud, C. Loveday, P. Martín-Gimeno, C. Meijer, J. Nsengimana, D. Quinn, T. Rafnar, S. Ramdas, L. Richiardi, R. Skotheim, K. Stefánsson, C. Turnbull, D. Vaughn, F. Wiklund, Xifeng Wu, Daphne Yang, T. Zheng, A. Wells, S. Grant, E. Rajpert‐De Meyts, S. Schwartz, D. Bishop, K. McGlynn, P. Kanetsky, K. Nathanson, C. Kubisch   +56 more
semanticscholar   +1 more source

PI3K/PTEN/AKT Signaling Pathways in Germ Cell Development and Their Involvement in Germ Cell Tumors and Ovarian Dysfunctions

International Journal of Molecular Sciences, 2021
Several studies indicate that the PI3K/PTEN/AKT signaling pathways are critical regulators of ovarian function including the formation of the germ cell precursors, termed primordial germ cells, and the follicular pool maintenance.
M. De Felici, F. Klinger
semanticscholar   +1 more source

Pembrolizumab in Patients with Advanced Metastatic Germ Cell Tumors.

The Oncologist, 2021
LESSONS LEARNED Advanced germ cell tumors are aggressive and associated with poor prognosis. Pembrolizumab was overall well-tolerated in 12 heavily pretreated patients.
A. Tsimberidou, H. Vo, V. Subbiah, F. Janku, S. Piha-Paul, B. Yılmaz, Jing Gong, Mohammad Faraz Naqvi, S. Tu, M. Campbell, F. Meric-Bernstam, A. Naing   +11 more
semanticscholar   +1 more source

DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency

Nature Communications, 2021
In vivo reprogramming provokes a wide range of cell fate conversion. Here, we discover that in vivo induction of higher levels of OSKM in mouse somatic cells leads to increased expression of primordial germ cell (PGC)-related genes and provokes genome ...
Jumpei Taguchi, H. Shibata, Mio Kabata, Masaki Kato, Kei Fukuda, A. Tanaka, S. Ohta, Tomoyo Ukai, Kanae Mitsunaga, Y. Yamada, So I. Nagaoka, S. Yamazawa, Kotaro Ohnishi, K. Woltjen, T. Ushiku, M. Ozawa, M. Saitou, Y. Shinkai, Takuya Yamamoto, Yasuhiro Yamada   +19 more
semanticscholar   +1 more source

Case Reports: Management Challenges in Pediatric Germ Cell Tumors

Frontiers in Pediatrics, 2021
Germ cell tumors in infants are most frequently extragonadal, benign, and amenable to surgical resection. An unusual feature of germ cell tumors is the potential coexistence of malignant with benign disease which makes it possible for patients with ...
Sophie Carr, Sophie Carr, Arash Safavi, Erik D. Skarsgard   +3 more
doaj   +1 more source

Klinefelter syndrome and germ cell tumors: review of the literature

International Journal of Pediatric Endocrinology, 2020
Objective The most common presentation of Klinefelter syndrome (KS) is infertility and features of hypogonadism. Currently no consensus exists on the risk of malignancy in this syndrome.
Kimberley Bonouvrie, J. E. van der Werff ten Bosch, M. van den Akker   +2 more
semanticscholar   +1 more source

Peculiarities of differential diagnosis of malignant and benign ovarian tumors in girls (case report of immature teratoma of the ovary)

Педиатрическая фармакология, 2023
Germ  cell tumors  are  a heterogeneous group  of tumors  differentiating from  primary germ  cells of  embryonic gonads and  their derivatives. This case  report demonstrates the diagnostic algorithm and diagnostic tactics of a rarely encountered ...
Elena V. Sibirskaya, Irina V. Karachentsova, Ivan N. Skapenkov, Andrey A. Naumenko, Ivan I. Petinov, Polina O. Nikiforova   +5 more
doaj   +1 more source

Preoperative Differentiation of Benign and Malignant Non-epithelial Ovarian Tumors: Clinical Features and Tumor Markers [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2020
Objective To evaluate the role of clinical features and preoperativemeasurement of cancer antigen 125 (CA125), human epididymis protein(HE4), and carcinoembryonic antigen (CEA) serum levels in women with benign and malignant non-epithelial ovarian ...
Tiago Augusto Gomes, Elizabeth Aparecida Campos, Adriana Yoshida, Luís Otavio Sarian, Liliana Aparecida Lucci de Angelo Andrade, Sophie Françoise Derchain   +5 more
doaj   +1 more source