Results 91 to 100 of about 5,138,444 (292)

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen [PDF]

, 2008
Spermatogenesis in the adult male depends on the action of FSH and androgen. Ablation of either hormone has deleterious effects on Sertoli cell function and the progression of germ cells through spermatogenesis.
Baker, P.J., Guillou, F., Abel, M.H., Verhoeven, G., De Gendt, K., Guillou, Florian Jean Louis, Charlton, H.M., Monteiro, A., O'Shaughnessy, P.J.   +8 more
core   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Séance GERM/RITMO (06/02/2017) : Lexique temporalité et rituel

, 2017
Le lundi 6 février 2017, de 10h à 13h Nous avons le plaisir de vous inviter à la prochaine réunion du GERM et du GDRI RITMO, Nous nous réunirons pour faire le point sur les avancées du lexique temporalité et rituel.
germ
core   +1 more source

Scrotal Involvement with Testicular Nonseminomatous Germ Cell Tumour

Case Reports in Oncological Medicine, 2016
A 37-year-old male presented with a traumatic injury to the scrotal region necessitating emergency surgery. Evacuation of a haematoma and bilateral orchidectomy were performed. A left sided nonseminomatous germ cell tumour (NSGCT), predominantly yolk sac,
C. G. O’Leary, J. A. Allen, F. O’Brien, A. Tuthill, D. G. Power   +4 more
doaj   +1 more source

GERM CELL TUMOURS: A Report of 72 Cases

, 1993
The Authours report a prospective Study of the diagnosis and treatment of Germ Cell Tumours in children since January ...
A. M. Fagnani M. Lo Cascio, M. Lo Curto, G. Provenzano, A. Zingone, M. R. Di Pace, F. Siracusa, G. Cecchetto, S. Bagnulo, B. De Bernardi   +8 more
core  

Primordial Germ Cell-Mediated Chimera Technology Produces Viable Pure-Line Houbara Bustard Offspring: Potential for Repopulating an Endangered Species [PDF]

, 2010
BACKGROUND: The Houbara bustard (Chlamydotis undulata) is a wild seasonal breeding bird populating arid sandy semi-desert habitats in North Africa and the Middle East.
Liu Chunhai, Baskar, Vijay, Saleem Shazia, Chang, Il-Kuk, Ulrich Wernery, Vijay Baskar, Shazia Saleem, Saleem, Shazia, Chunhai Liu, Il-Kuk Chang, Guerineche, Zhor, Baskar Vijay, Khazanehdari, Kamal A., Kamal A. Khazanehdari, Wernery, Renate, Wernery Renate, Darren K Griffin, Milstone, David S., Zhor Guerineche, Griffin Darren K., Liu, Chunhai, Kinne, Jörg, Khazanehdari Kamal A., Darren K. Griffin, Renate Wernery, Guerineche Zhor, Kamal A Khazanehdari, Jörg Kinne, Wernery, Ulrich, Wernery Ulrich, Kinne Jörg, Griffin, Darren K., Chang Il-Kuk   +32 more
core   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

The value of ultrasound texture analysis in the diagnosis of pathological types of primary testicular tumours in adults

BMC Cancer
Background Different types of testicular tumours require different treatments. Malignant germ cell tumours usually require radical orchiectomy, while benign tumours may only require excision of the mass.
Danhong Yu, Nianyu Xue
doaj   +1 more source