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Current Opinion in Oncology, 2005
This review provides an overview of some of the recent pre-clinical and clinical developments in germ cell tumors.Recent epidemiological studies highlight the variations in the geographic and ethnic distribution of germ cell tumors and the changing incidence of seminoma versus nonseminoma in the population. Additional studies are continuing to identify
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This review provides an overview of some of the recent pre-clinical and clinical developments in germ cell tumors.Recent epidemiological studies highlight the variations in the geographic and ethnic distribution of germ cell tumors and the changing incidence of seminoma versus nonseminoma in the population. Additional studies are continuing to identify
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Germ cell lineage differentiation in non‐seminomatous germ cell tumours
The Journal of Pathology, 2005AbstractHuman germ cell tumours (GCTs) have long fascinated investigators for a number of reasons. Being pluripotential tumours, they can differentiate into both extra‐embryonic and embryonic (somatic) tissues. However, it has never been shown convincingly that, in humans, these tumours are truly totipotent and can also give rise to the germ lineage ...
Honecker, F +7 more
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Germ cell-Sertoli cell interactions
Reproduction, Fertility and Development, 1990The interactions between the Sertoli cells and germ cells are progressively becoming an important part of testicular physiology. This paper explores the cytological basis for these interactions, detailing the cyclic changes in the Sertoli cells in concert with the stages of the seminiferous cycle and the nature of the blood-testis barrier.
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Germ cells and germ cell transplantation.
The International journal of developmental biology, 1999The germ cell lineage in mice is established about a week after fertilization, in a group of cells that have left the epiblast and moved to an extraembryonic site. They migrate back into the embryo, along the hind gut and into the gonads. Germ cells in male and female embryos then pursue different pathways: in the testis the germ cells cease ...
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How germ granules promote germ cell fate
Nature Reviews GeneticsGerm cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble membraneless germ granules. These specialized RNA and protein complexes are hallmarks of germ cells throughout their life cycle: as embryonic germ granules in late oocytes and zygotes, Balbiani bodies in immature ...
Melissa C. Pamula, Ruth Lehmann
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[Embryonal germ cells and germ cell tumors].
Verhandlungen der Deutschen Gesellschaft fur Pathologie, 2008Testicular germ cell tumors comprise of group of pluripotent tumors including seminomas and nonseminomas, arise from intratubular germ cell neoplasia and originate from the primordial germ cells/ gonocytes. Many well characterized markers of embryonic stem cells including CD9, PODXL and centromere-specific histone-H3-like protein CENPA are consistently
K, Biermann +14 more
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Male Germ Cell Transplantation
Reproduction in Domestic Animals, 2008ContentsTransplantation of male germ line stem cells from a donor animal to the testes of an infertile recipient was first described in 1994. Donor germ cells colonize the recipient’s testis and produce donor‐derived sperm, such that the recipient male can distribute the genetic material of the germ cell donor.
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Seminars in Surgical Oncology, 1999
Pediatric germ cell tumors represent a diverse group of tumors that present from in utero through adolescence at many nongonadal locations, from the neck to the sacrococcygeal region. Surgical resection remains the central element of management, and accurate surgical staging is essential to properly ascertain the correct risk-based treatment.
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Pediatric germ cell tumors represent a diverse group of tumors that present from in utero through adolescence at many nongonadal locations, from the neck to the sacrococcygeal region. Surgical resection remains the central element of management, and accurate surgical staging is essential to properly ascertain the correct risk-based treatment.
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1991
In this chapter, I will discuss the cultivation in vitro of cells from biopsy specimens of human testicular germ cell tumours. These fascinating tumours command the attention of oncologists and biologists for several reasons. From the standpoint of the cancer therapist, while germ cell tumours represent one of the few success stories achieved with ...
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In this chapter, I will discuss the cultivation in vitro of cells from biopsy specimens of human testicular germ cell tumours. These fascinating tumours command the attention of oncologists and biologists for several reasons. From the standpoint of the cancer therapist, while germ cell tumours represent one of the few success stories achieved with ...
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2006
erm cell development in mammalian gametogenesis involves a complex sequence of events regulated by a large variety of molecules. Although hormones have been always considered the primary regulators of gametogenesis, it is now well established that growth factors (GFs) in concert and against or in some case autonomously of hormones, may control or ...
ROSSI, PELLEGRINO +3 more
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erm cell development in mammalian gametogenesis involves a complex sequence of events regulated by a large variety of molecules. Although hormones have been always considered the primary regulators of gametogenesis, it is now well established that growth factors (GFs) in concert and against or in some case autonomously of hormones, may control or ...
ROSSI, PELLEGRINO +3 more
openaire +1 more source