Results 91 to 100 of about 3,781,098 (345)

Validity of two Higgs doublet models with a scalar color octet up to a high energy scale

open access: yes, 2017
We have recently studied theoretical constraints on the parameters of a 2HDM augmented with a color-octet scalar. In this paper we consider the consequences of requiring the model to remain valid up to very high energy scales, such as the GUT scale.
Cheng, Li, Valencia, German
core   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Emphatic stress shift in German

open access: yesZeitschrift für Sprachwissenschaft, 2008
This paper presents an analysis of a sample of intentional deviations from the typical stress pattern of German words. These deviations are described as stress shifts in which the main stress is in a different position to the norm.
Berg Thomas
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

The Morphological Trigger of V-to-T: The Case of Old English

open access: yesStudia Anglica Posnaniensia, 2016
This paper deals with the phenomenon of V-to-T movement, which is one of the major parameters differentiating Romance from the majority of modern Germanic languages, and it defends the idea that rich morphology is the cause or trigger of V-to-T: in ...
Castillo Concha
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Investigating Copyright Terminology and Collocations in Polish, English, Japanese and German

open access: yesStudies in Logic, Grammar and Rhetoric, 2017
The article deals with the comparison of key terminology in the field of copyright in the Polish, English, Japanese and German languages. The research material consists of copyright acts binding in Poland, Great Britain, the United States of America ...
Trzaskawka Paula
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

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