Results 111 to 120 of about 1,872,140 (297)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2006 Öğrenmeye başladığımız ilk günden ulaştığımız yaşa kadar, sürekli bir şekilde yeni şeylerin isimlerini sözcük dağarcığımıza katıyoruz. 8 sözcük türünden biri olan sıfatlar, nesneleri algılamada, tanımlamada ve ayırt etmede önemli bir görev üstlenirler ...
Rıdvan Tunçel
doaj
Validation of the German version of the Perceived Cohesion Scale
International Journal of Occupational Medicine and Environmental HealthObjectives Team or group cohesion is a multifaceted construct with a variety of definitions and measurement instruments. However, most of these measures are context and group-specific and/or time-consuming.
Marietta Lieb +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
AlephEvaluation is a key pedagogical act in the process of teaching and learning foreign languages. It is fundamental and unavoidable in the various education systems.
Karima Meghouche
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Magazine of the German Reformed Church, Vol. 4 No. 9
Digitized copy of the September 1831 issue of the Magazine of the German Reformed Church. Electronic PDF document.
German Reformed Church (U.S.)
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German-Texan Heritage Society Journal
, 1999 Quarterly publication of the German-Texan Heritage Society providing information about news and events related to the work of the organization as well as stories, articles, genealogical data and other information of interest to members collected from ...
German-Texan Heritage Society +1 more
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