Results 51 to 60 of about 823,331 (263)
Dil ve Edebiyat Araştırmaları Dergisi, 2019 The Battle of Mohàcs (1526) resulted in important consequences by means of Turkish and European history. Consequences of this Battle is important for the Turkish language as well as political and economical aspect.
Beytullah Bekar
doaj +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Musicology and German National Identity
Central Europe, 2019 This article explores the concept of German national identity as it has been used by musicologists and offers an alternative, fuller understanding of that concept by placing it in its late eighteenth-century context.
Emily Jane Clink
doaj
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Intergenerational service-learning through virtual exchange across a foreign language program
Journal of Virtual ExchangeThis paper reports on the implementation of intergenerational service-learning (SL) through virtual exchange (VE) across a German as a foreign language program at a private research institution on the East Coast in the U.S.
Carolin Fuchs
doaj +1 more source
, 2017 Before 1850 Herman Melville was a fairly typical American male, in that he was rebellious and needed to earn money to live. He had left school early, and by the time he began work on Moby-Dick; or, The Whale he had been a bank clerk, shop assistant, school teacher and a merchant seaman.
openaire +3 more sources